Tumor Necrosis Factor Alpha Differentially Regulates Beta- Endorphin Concentrations And Proopiomelanocortin Rna In The Anterior And Neurointermediate Pituitary In Vivo

Paola Sacerdote; Anna T. Brinia; Luisa Locatelli; Jelena Radulovic; Alberto E. Panerai

doi:10.1159/000097188

Tumor Necrosis Factor Alpha Differentially Regulates Beta- Endorphin Concentrations And Proopiomelanocortin Rna In The Anterior And Neurointermediate Pituitary In Vivo

Paola Sacerdote^*, Anna T. Brinia, Luisa Locatelli, Jelena Radulovic, Alberto E. Panerai

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

We analyzed the effect of tumor necrosis factor α (TNF- α) on β-endorphin concentrations and proopiomelanocortin mRNA in the rat anterior and neurointermediate pituitaries. The intraperitoneal injection of 5 μg/kg TNF- α decreases β-endorphin in neurointermediate pituicytes 4, 8 and 24 h after the treatment without affecting proopiomelanocortin (POMC) RNA. In contrast, in the anterior pituitary 4 h after the injection of the cytokine, POMC RNA was decreased while the peptide content was increased. These effects can be relevant to the modulation of the pituitary-adrenal axis and immune responses in conditions, such as infections, in which TNF levels are increased.

Original language	English (US)
Pages (from-to)	357-360
Number of pages	4
Journal	Neuroimmunomodulation
Volume	1
Issue number	6
DOIs	https://doi.org/10.1159/000097188
State	Published - 1994

Keywords

Cytokines
Pituitary
Proopiomelanocortin
Tumor necrosis factor α
β-Endorphin

ASJC Scopus subject areas

Endocrine and Autonomic Systems
Neurology
Endocrinology
Immunology

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10.1159/000097188

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title = "Tumor Necrosis Factor Alpha Differentially Regulates Beta- Endorphin Concentrations And Proopiomelanocortin Rna In The Anterior And Neurointermediate Pituitary In Vivo",

abstract = "We analyzed the effect of tumor necrosis factor α (TNF- α) on β-endorphin concentrations and proopiomelanocortin mRNA in the rat anterior and neurointermediate pituitaries. The intraperitoneal injection of 5 μg/kg TNF- α decreases β-endorphin in neurointermediate pituicytes 4, 8 and 24 h after the treatment without affecting proopiomelanocortin (POMC) RNA. In contrast, in the anterior pituitary 4 h after the injection of the cytokine, POMC RNA was decreased while the peptide content was increased. These effects can be relevant to the modulation of the pituitary-adrenal axis and immune responses in conditions, such as infections, in which TNF levels are increased.",

keywords = "Cytokines, Pituitary, Proopiomelanocortin, Tumor necrosis factor α, β-Endorphin",

author = "Paola Sacerdote and Brinia, {Anna T.} and Luisa Locatelli and Jelena Radulovic and Panerai, {Alberto E.}",

year = "1994",

doi = "10.1159/000097188",

language = "English (US)",

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AU - Sacerdote, Paola

AU - Brinia, Anna T.

AU - Locatelli, Luisa

AU - Radulovic, Jelena

AU - Panerai, Alberto E.

PY - 1994

Y1 - 1994

N2 - We analyzed the effect of tumor necrosis factor α (TNF- α) on β-endorphin concentrations and proopiomelanocortin mRNA in the rat anterior and neurointermediate pituitaries. The intraperitoneal injection of 5 μg/kg TNF- α decreases β-endorphin in neurointermediate pituicytes 4, 8 and 24 h after the treatment without affecting proopiomelanocortin (POMC) RNA. In contrast, in the anterior pituitary 4 h after the injection of the cytokine, POMC RNA was decreased while the peptide content was increased. These effects can be relevant to the modulation of the pituitary-adrenal axis and immune responses in conditions, such as infections, in which TNF levels are increased.

AB - We analyzed the effect of tumor necrosis factor α (TNF- α) on β-endorphin concentrations and proopiomelanocortin mRNA in the rat anterior and neurointermediate pituitaries. The intraperitoneal injection of 5 μg/kg TNF- α decreases β-endorphin in neurointermediate pituicytes 4, 8 and 24 h after the treatment without affecting proopiomelanocortin (POMC) RNA. In contrast, in the anterior pituitary 4 h after the injection of the cytokine, POMC RNA was decreased while the peptide content was increased. These effects can be relevant to the modulation of the pituitary-adrenal axis and immune responses in conditions, such as infections, in which TNF levels are increased.

KW - Cytokines

KW - Pituitary

KW - Proopiomelanocortin

KW - Tumor necrosis factor α

KW - β-Endorphin

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Tumor Necrosis Factor Alpha Differentially Regulates Beta- Endorphin Concentrations And Proopiomelanocortin Rna In The Anterior And Neurointermediate Pituitary In Vivo

Abstract

Keywords

ASJC Scopus subject areas

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