Tumor relapse prevented by combining adoptive T cell therapy with Salmonella typhimurium

David C. Binder*, Ainhoa Arina, Frank Wen, Tony Tu, Ming Zhao, Robert M. Hoffman, Derek A. Wainwright, Hans Schreiber

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

We recently reported that therapeutic vaccination with live tumor antigen-producing Salmonella typhimurium rescues dysfunctional endogenous T cell responses and eradicates long-established tumors refractory to αCTLA-4 and αPD-L1 checkpoint inhibitor blockade. Here, we show that live intravenously injected or heat-killed (HK) intratumorally injected Salmonella typhimurium, even when not producing tumor antigen, synergize with adoptive T cell therapy to eradicate tumors. These data demonstrate that the combination of adoptive T cell transfer with the injection of live or dead Salmonella typhimurium is a promising approach for cancer treatment.

Original languageEnglish (US)
Article numbere1130207
JournalOncoImmunology
Volume5
Issue number6
DOIs
StatePublished - Jun 2 2016

Keywords

  • Adoptive T cell therapy
  • bacteria
  • macrophage
  • relapse
  • tumor stroma

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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