Tumor suppression by resistant maltodextrin, Fibersol-2

Eui Young So, Mutsuko Ouchi, Sara Cuesta-Sancho, Susan Losee Olson, Dirk Reif, Kazuhiro Shimomura, Toru Ouchi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Resistant maltodextrin Fibersol-2 is a soluble and fermentable dietary fiber that is Generally Recognized As Safe (GRAS) in the United States. We tested whether Fibersol-2 contains anti-tumor activity. Human colorectal cancer cell line, HCT116, and its isogenic cells were treated with FIbersol-2. Tumor growth and tumorigenesis were studied in vitro and in vivo. Apoptotic pathway and generation of reactive oxygen species (ROS) were investigated. We discovered that Fibersol-2 significantly inhibits tumor growth of HCT116 cells by inducing apoptosis. Fibersol-2 strongly induces mitochondrial ROS and Bax-dependent cleavage of caspase 3 and 9, which is shown by isogenic HCT116 variants. Fibersol-2 induces phosphorylation of Akt, mTOR in parental HCT116 cells, but not in HCT116 deficient for Bax or p53. It prevents growth of tumor xenograft without any apparent signs of toxicity in vivo. These results identify Fibersol-2 as a mechanism-based dietary supplement agent that could prevent colorectal cancer development.

Original languageEnglish (US)
Pages (from-to)460-465
Number of pages6
JournalCancer Biology and Therapy
Volume16
Issue number3
DOIs
StatePublished - Mar 1 2015

Keywords

  • Apoptosis
  • Colorectal cancer
  • Fibersol-2
  • Reactive oxygen species
  • Resistant maltodextrin
  • p53

ASJC Scopus subject areas

  • Molecular Medicine
  • Oncology
  • Pharmacology
  • Cancer Research

Fingerprint

Dive into the research topics of 'Tumor suppression by resistant maltodextrin, Fibersol-2'. Together they form a unique fingerprint.

Cite this