Tumor-suppressive maspin functions as a reactive oxygen species scavenger: Importance of cysteine residues

Nitin Mahajan, Heidi Y. Shi, Thomas J. Lukas, Ming Zhang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Background: Maspin is a multifaceted serpin, but the role of intracellular maspin is still not well understood. Results: Our study provides evidence that the structurally exposed cysteine residues in maspin reduce oxidative stress and cell proliferation. Conclusion: Cysteine thiols in maspin scavenge reactive oxygen species in tumor cells. Significance: These findings elucidate the importance of cysteine residues of maspin in curbing oxidative stress.

Original languageEnglish (US)
Pages (from-to)11611-11620
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number16
DOIs
StatePublished - Apr 19 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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