TY - JOUR
T1 - Tumor-to-tumor metastasis
T2 - Breast carcinoma to meningioma
AU - Sayegh, Eli T.
AU - Burch, Ezra A.
AU - Henderson, Grant A.
AU - Oh, Taemin
AU - Bloch, Orin
AU - Parsa, Andrew T.
N1 - Funding Information:
This work was supported by grants from the Howard Hughes Medical Institute (E.T.S.), the Reza and Georgianna Khatib Endowed Chair in Skull Base Tumor Surgery at UCSF (A.T.P.), and the Michael J. Marchese Professor and Chair at Northwestern University (A.T.P.).
Publisher Copyright:
© 2014 Published by Elsevier Ltd.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Metastasis of breast carcinoma to meningioma is a rare phenomenon with relatively few reports in the literature, although it is the most common type of carcinoma-to-meningioma metastasis. Several factors have been implicated in the pathogenesis of these lesions, including the microenvironment and vascular network of the meningioma, expression of cell-cell adhesion molecules, local immunosuppression, and hormonal factors, including estrogen and progesterone, whose receptors have been well-characterized in these two tumor types. While histopathologic study is the cornerstone of diagnosis of these lesions, newer radiological modalities such as magnetic resonance spectroscopy and perfusion MRI have shown promise, particularly in screening patients at risk for developing these lesions. Because their detection is problematic, it is imperative that clinicians thoroughly examine tissue samples of resected meningiomas, as this may alter the patient's treatment plan and prognosis. Furthermore, as both of these neoplasms often co-occur in women with breast cancer, clinicians should be vigilant of the potential for intrameningioma metastasis when neurological involvement becomes apparent in late-stage disease. While these unusual lesions should be managed surgically, as with meningiomas, it is unclear whether proposed adjuvants such as hormonal and radiation therapy improve survival.
AB - Metastasis of breast carcinoma to meningioma is a rare phenomenon with relatively few reports in the literature, although it is the most common type of carcinoma-to-meningioma metastasis. Several factors have been implicated in the pathogenesis of these lesions, including the microenvironment and vascular network of the meningioma, expression of cell-cell adhesion molecules, local immunosuppression, and hormonal factors, including estrogen and progesterone, whose receptors have been well-characterized in these two tumor types. While histopathologic study is the cornerstone of diagnosis of these lesions, newer radiological modalities such as magnetic resonance spectroscopy and perfusion MRI have shown promise, particularly in screening patients at risk for developing these lesions. Because their detection is problematic, it is imperative that clinicians thoroughly examine tissue samples of resected meningiomas, as this may alter the patient's treatment plan and prognosis. Furthermore, as both of these neoplasms often co-occur in women with breast cancer, clinicians should be vigilant of the potential for intrameningioma metastasis when neurological involvement becomes apparent in late-stage disease. While these unusual lesions should be managed surgically, as with meningiomas, it is unclear whether proposed adjuvants such as hormonal and radiation therapy improve survival.
KW - Breast carcinoma
KW - Meningioma
KW - Metastasis
KW - Tumor-to-tumor
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U2 - 10.1016/j.jocn.2014.07.002
DO - 10.1016/j.jocn.2014.07.002
M3 - Review article
C2 - 25150768
AN - SCOPUS:84920659870
SN - 0967-5868
VL - 22
SP - 268
EP - 274
JO - Journal of Clinical Neuroscience
JF - Journal of Clinical Neuroscience
IS - 2
ER -