Tumor treating fields: A novel treatment modality and its use in brain tumors

Andreas F. Hottinger*, Patricia Pacheco, Roger Stupp

*Corresponding author for this work

Research output: Contribution to journalReview article

51 Scopus citations

Abstract

Tumor treating fields (TTFields) are low-intensity electric fields alternating at an intermediate frequency (200kHz), which have been demonstrated to block cell division and interfere with organelle assembly. This novel treatment modality has shown promise in a variety of tumor types. It has been evaluated in randomized phase 3 trials in glioblastoma (GBM) and demonstrated to prolong progression-free survival (PFS) and overall survival (OS) when administered together with standard maintenance temozolomide (TMZ) chemotherapy in patients with newly diagnosed GBM. TTFields are continuously delivered by 4 transducer arrays consisting each of 9 insulated electrodes that are placed on the patient's shaved scalp and connected to a portable device. Here we summarize the preclinical data and mechanism of action, the available clinical data, and further outlook of this treatment modality in brain tumors and other cancer indications.

Original languageEnglish (US)
Pages (from-to)1338-1349
Number of pages12
JournalNeuro-oncology
Volume18
Issue number10
DOIs
StatePublished - Oct 1 2016

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ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology
  • Cancer Research

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