Tumoral angiogenesis in both adrenal adenomas and nonadenomas: A promising computed tomography biomarker for diagnosis

Xifu Wang, Kangan Li, Haoran Sun, Jinglong Zhao, Zhuoli Zhang, Linfeng Zheng, Weiguo Li, Renju Bai*, Guixiang Zhang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


To explore the correlation between the typical findings of dynamic contrast-enhanced computed tomography (DCE-CT) and tumoral angiogenesis (microvessel density [MVD] and vascular endothelial growth factor [VEGF]) in adenomas and nonadenomas such that the enhancement mechanism of DCE-CT in adrenal masses can be explained more precisely. Forty-two patients with 46 adrenal masses confirmed by surgery and pathology were included in the study; these masses included 23 adenomas, 18 nonadenomas, and 5 hyperplastic nodules. The findings of DCE-CT and angiogenesis in adrenal masses were studied. The features of DCE-CT in adenomas and nonadenomas were evaluated to determine whether the characteristics of DCE-CT in adrenal masses were closely correlated with tumoral angiogenesis. Adrenal adenomas were significantly different from nonadenomas in the time density curve and the mean percentage of enhancement washout at the 7-minute delay time in DCE-CT. The mean MVD and VEGF expression exhibited significant differences between the rapid washout group (types A and C) and the slow washout group (types B, D, and E) and between the relative washout (Washr) ≥34% and the absolute washout (Washa) ≥43% on the 7-minute enhanced CT scans (P=0.000). Adenomas were suggested when adrenal masses presented as types A and C, and/or the Washr ≥34%, and/or the Washa ≥43%, and the opposite was suggested for nonadenomas. These results showed a close correlation between the characteristics of DCE-CT and both MVD and VEGF expression in adrenal masses. There was also a significant difference in MVD and VEGF expression between adenomas and nonadenomas. In conclusion, MVD and VEGF expression are two important pathological factors that play important roles in the characterization of DCE-CT in adrenal masses because they cause different time density curve types, the Washr and the Washa for adrenal adenomas and nonadenomas.

Original languageEnglish (US)
Pages (from-to)1823-1830
Number of pages8
JournalOncoTargets and Therapy
StatePublished - Mar 30 2016


  • Adrenal adenomas and nonadenomas
  • Biomarker
  • Diagnosis
  • Tumoral angiongenesis
  • X-ray computed tomography

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)


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