Tumorigenicity of the hypolipidaemic peroxisome proliferator ethyl-α-p-chlorophenoxyisobutyrate (clofibrate) in rats

J. K. Reddy, S. A. Qureshi

Research output: Contribution to journalArticle

141 Scopus citations

Abstract

Ethyl-α-p-chlorophenoxyisobutyrate), a hypolipidaemic drug which induces hepatomegaly and proliferation of peroxisomes in liver cells of rats and mice, was fed to 15 male F344 rats at a dietary concentration of 0.5% (v/w) for up to 28 months. Hepatocellular carcinomas developed in 10/11 (91%) rats killed between 24 and 28 months. Other tumours included carcinoma of the pancreas (2 rats), leiomyoma of the small intestine (1 rat) and a large dermatofibrosarcoma (1 rat). Clofibrate is the third hypolipidaemic peroxisome proliferator demonstrated to be hepatocarcinogenic in rats. These studies suggest that hypolipidaemic agents which are capable of producing a sustained hepatomegalic and peroxisome-proliferative effect also induce liver tumours.

Original languageEnglish (US)
Pages (from-to)476-482
Number of pages7
JournalBritish Journal of Cancer
Volume40
Issue number3
DOIs
StatePublished - Sep 1979

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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