Tunable biomolecular interaction and fluorescence quenching ability of graphene oxide: Application to "turn-on" dna sensing in biological media

Bong Jin Hong, Zhi An, Owen C. Compton, Sonbinh T. Nguyen*

*Corresponding author for this work

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

As a platform for "turn-on" DNA sensing, the level of oxidation of graphene oxide strongly affects its fluorescence quenching ability and binding interactions to single-stranded oligodeoxyribonucleotides (ssODNs), leading to a broad range of sensitivity. Fine-tuning the level of oxidation of graphene oxide yields a DNA-detection platform that is highly sensitive in serum and biological media.

Original languageEnglish (US)
Pages (from-to)2469-2476
Number of pages8
JournalSmall
Volume8
Issue number16
DOIs
StatePublished - Aug 20 2012

Keywords

  • DNA sensor
  • biomolecular interaction
  • fluorescence quenching
  • graphene oxide
  • tunability

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

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