Tunable biomolecular interaction and fluorescence quenching ability of graphene oxide: Application to "turn-on" dna sensing in biological media

Bong Jin Hong; Zhi An; Owen C. Compton; Sonbinh T. Nguyen

doi:10.1002/smll.201200264

Tunable biomolecular interaction and fluorescence quenching ability of graphene oxide: Application to "turn-on" dna sensing in biological media

Bong Jin Hong, Zhi An, Owen C. Compton, Sonbinh T. Nguyen^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

As a platform for "turn-on" DNA sensing, the level of oxidation of graphene oxide strongly affects its fluorescence quenching ability and binding interactions to single-stranded oligodeoxyribonucleotides (ssODNs), leading to a broad range of sensitivity. Fine-tuning the level of oxidation of graphene oxide yields a DNA-detection platform that is highly sensitive in serum and biological media.

Original language	English (US)
Pages (from-to)	2469-2476
Number of pages	8
Journal	Small
Volume	8
Issue number	16
DOIs	https://doi.org/10.1002/smll.201200264
State	Published - Aug 20 2012

Keywords

DNA sensor
biomolecular interaction
fluorescence quenching
graphene oxide
tunability

ASJC Scopus subject areas

General Chemistry
General Materials Science
Biotechnology
Biomaterials

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10.1002/smll.201200264

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AU - An, Zhi

AU - Compton, Owen C.

AU - Nguyen, Sonbinh T.

PY - 2012/8/20

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AB - As a platform for "turn-on" DNA sensing, the level of oxidation of graphene oxide strongly affects its fluorescence quenching ability and binding interactions to single-stranded oligodeoxyribonucleotides (ssODNs), leading to a broad range of sensitivity. Fine-tuning the level of oxidation of graphene oxide yields a DNA-detection platform that is highly sensitive in serum and biological media.

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KW - biomolecular interaction

KW - fluorescence quenching

KW - graphene oxide

KW - tunability

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Tunable biomolecular interaction and fluorescence quenching ability of graphene oxide: Application to "turn-on" dna sensing in biological media

Abstract

Keywords

ASJC Scopus subject areas

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