Tuning the intracellular bacterial targeting of peptidic vectors

Eric K. Lei, Mark P. Pereira, Shana O. Kelley*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Engineered vectors for intracellular targeting: Engineered peptides were used as a methotrexate delivery vector against intracellular L. monocytogenes. A peptide library was developed to determine the chemical properties required for specific drug delivery to bacteria while maintaining mitochondrial localization as a drug reservoir. Mtx-peptide conjugates were found to have higher antimicrobial activity and lower human cell toxicity.

Original languageEnglish (US)
Pages (from-to)9660-9663
Number of pages4
JournalAngewandte Chemie - International Edition
Volume52
Issue number37
DOIs
StatePublished - Sep 9 2013
Externally publishedYes

Keywords

  • antibacterial drugs
  • intracellular targeting
  • peptides

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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