Tuning the intracellular bacterial targeting of peptidic vectors

Eric K. Lei; Mark P. Pereira; Shana O. Kelley

doi:10.1002/anie.201302265

Tuning the intracellular bacterial targeting of peptidic vectors

Eric K. Lei, Mark P. Pereira, Shana O. Kelley^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Engineered vectors for intracellular targeting: Engineered peptides were used as a methotrexate delivery vector against intracellular L. monocytogenes. A peptide library was developed to determine the chemical properties required for specific drug delivery to bacteria while maintaining mitochondrial localization as a drug reservoir. Mtx-peptide conjugates were found to have higher antimicrobial activity and lower human cell toxicity.

Original language	English (US)
Pages (from-to)	9660-9663
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	37
DOIs	https://doi.org/10.1002/anie.201302265
State	Published - Sep 9 2013
Externally published	Yes

Keywords

antibacterial drugs
intracellular targeting
peptides

ASJC Scopus subject areas

General Chemistry
Catalysis

Access to Document

10.1002/anie.201302265

Cite this

@article{3d6511f299f8438094981f233480df58,

title = "Tuning the intracellular bacterial targeting of peptidic vectors",

abstract = "Engineered vectors for intracellular targeting: Engineered peptides were used as a methotrexate delivery vector against intracellular L. monocytogenes. A peptide library was developed to determine the chemical properties required for specific drug delivery to bacteria while maintaining mitochondrial localization as a drug reservoir. Mtx-peptide conjugates were found to have higher antimicrobial activity and lower human cell toxicity.",

keywords = "antibacterial drugs, intracellular targeting, peptides",

author = "Lei, {Eric K.} and Pereira, {Mark P.} and Kelley, {Shana O.}",

year = "2013",

month = sep,

day = "9",

doi = "10.1002/anie.201302265",

language = "English (US)",

volume = "52",

pages = "9660--9663",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "37",

}

TY - JOUR

T1 - Tuning the intracellular bacterial targeting of peptidic vectors

AU - Lei, Eric K.

AU - Pereira, Mark P.

AU - Kelley, Shana O.

PY - 2013/9/9

Y1 - 2013/9/9

N2 - Engineered vectors for intracellular targeting: Engineered peptides were used as a methotrexate delivery vector against intracellular L. monocytogenes. A peptide library was developed to determine the chemical properties required for specific drug delivery to bacteria while maintaining mitochondrial localization as a drug reservoir. Mtx-peptide conjugates were found to have higher antimicrobial activity and lower human cell toxicity.

AB - Engineered vectors for intracellular targeting: Engineered peptides were used as a methotrexate delivery vector against intracellular L. monocytogenes. A peptide library was developed to determine the chemical properties required for specific drug delivery to bacteria while maintaining mitochondrial localization as a drug reservoir. Mtx-peptide conjugates were found to have higher antimicrobial activity and lower human cell toxicity.

KW - antibacterial drugs

KW - intracellular targeting

KW - peptides

UR - http://www.scopus.com/inward/record.url?scp=84883542016&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84883542016&partnerID=8YFLogxK

U2 - 10.1002/anie.201302265

DO - 10.1002/anie.201302265

M3 - Article

C2 - 23893882

AN - SCOPUS:84883542016

SN - 1433-7851

VL - 52

SP - 9660

EP - 9663

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 37

ER -

Tuning the intracellular bacterial targeting of peptidic vectors

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this