Turning a stroke into a TIA: Curative thrombolysis with combined intravenous and intra-arterial tPA

David J. Gladstone, Richard I. Aviv, Babak Jahromi, Sandra E. Black, Devra Baryshnik, Rochelle Caratao, Allan J. Fox

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Intravenous tissue plasminogen activator (tPA) is standard treatment for eligible patients with acute ischemic stroke, but may be less effective for very severe strokes caused by proximal intracranial artery occlusions. We report the case of a woman with a devastating stroke who recovered completely following emergency revascularization of an occluded proximal middle cerebral artery using a novel treatment approach that combines both intravenous (IV) and intra-arterial (IA) tPA. This case illustrates the potential value of the combined IV-IA thrombolytic approach, which is an emerging investigational treatment strategy for selected patients with severe acute ischemic stroke.

Original languageEnglish (US)
Pages (from-to)54-57
Number of pages4
JournalCanadian Journal of Emergency Medicine
Volume8
Issue number1
DOIs
StatePublished - Jan 2006

Keywords

  • Acute ischemic stroke
  • IV-IA thrombolytic approach
  • Intra-arterial tPA
  • Intravenous tPA

ASJC Scopus subject areas

  • Emergency Medicine

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