Turning down the volume on transcriptional noise

Daniel Neems; Steven T. Kosak

doi:10.1038/ncb1010-929

Turning down the volume on transcriptional noise

Daniel Neems^*, Steven T. Kosak

^*Corresponding author for this work

Cell & Developmental Biology

Research output: Contribution to journal › Short survey › peer-review

5 Scopus citations

Abstract

Transcriptional noise has an important role in generating diversity in cellular populations that are seemingly identical. As this noise stems from the inherent stochasticity of gene expression, it has been unclear whether it is directly controlled. Dig1, a regulator of the budding yeast mating pathway, is now shown to prevent transcriptional noise by regulating the spatial organization of downstream gene targets.

Original language	English (US)
Pages (from-to)	929-931
Number of pages	3
Journal	Nature Cell Biology
Volume	12
Issue number	10
DOIs	https://doi.org/10.1038/ncb1010-929
State	Published - Oct 2010

ASJC Scopus subject areas

Cell Biology

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10.1038/ncb1010-929

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AB - Transcriptional noise has an important role in generating diversity in cellular populations that are seemingly identical. As this noise stems from the inherent stochasticity of gene expression, it has been unclear whether it is directly controlled. Dig1, a regulator of the budding yeast mating pathway, is now shown to prevent transcriptional noise by regulating the spatial organization of downstream gene targets.

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Turning down the volume on transcriptional noise

Abstract

ASJC Scopus subject areas

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