Turning on cell migration with electroactive substrates

Muhammad N. Yousaf; Benjamin T. Houseman; Milan Mrksich

doi:10.1002/1521-3773(20010316)40:6<1093::AID-ANIE10930>3.0.CO;2-Q

Turning on cell migration with electroactive substrates

Muhammad N. Yousaf^*, Benjamin T. Houseman, Milan Mrksich

^*Corresponding author for this work

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

158 Scopus citations

Abstract

A dynamic surface can "turn on" the migration of adherent cells. This dynamic property is based on a self-assembled monolayer that presents hydroquinone groups. Electrochemical oxidation converts the hydroquinone into the corresponding benzoquinone, which then undergoes a Diels-Alder reaction with a conjugate of cyclopentadiene and a peptide ligand. This in situ modification of the substrate gives a surface that promotes cell migration (see scheme).

Original language	English (US)
Pages (from-to)	1093-1096
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	40
Issue number	6
DOIs	https://doi.org/10.1002/1521-3773(20010316)40:6<1093::AID-ANIE10930>3.0.CO;2-Q
State	Published - Mar 14 2001

Keywords

Bioorganic chemistry
Cell migration
Diels-Alder reaction
Monolayers
Oxidation

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/1521-3773(20010316)40:6<1093::AID-ANIE10930>3.0.CO;2-Q

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title = "Turning on cell migration with electroactive substrates",

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AU - Houseman, Benjamin T.

AU - Mrksich, Milan

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N2 - A dynamic surface can "turn on" the migration of adherent cells. This dynamic property is based on a self-assembled monolayer that presents hydroquinone groups. Electrochemical oxidation converts the hydroquinone into the corresponding benzoquinone, which then undergoes a Diels-Alder reaction with a conjugate of cyclopentadiene and a peptide ligand. This in situ modification of the substrate gives a surface that promotes cell migration (see scheme).

AB - A dynamic surface can "turn on" the migration of adherent cells. This dynamic property is based on a self-assembled monolayer that presents hydroquinone groups. Electrochemical oxidation converts the hydroquinone into the corresponding benzoquinone, which then undergoes a Diels-Alder reaction with a conjugate of cyclopentadiene and a peptide ligand. This in situ modification of the substrate gives a surface that promotes cell migration (see scheme).

KW - Bioorganic chemistry

KW - Cell migration

KW - Diels-Alder reaction

KW - Monolayers

KW - Oxidation

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ER -

Turning on cell migration with electroactive substrates

Abstract

Keywords

ASJC Scopus subject areas

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