Turning on cell migration with electroactive substrates

Muhammad N. Yousaf*, Benjamin T. Houseman, Milan Mrksich

*Corresponding author for this work

Research output: Contribution to journalArticle

148 Scopus citations

Abstract

A dynamic surface can "turn on" the migration of adherent cells. This dynamic property is based on a self-assembled monolayer that presents hydroquinone groups. Electrochemical oxidation converts the hydroquinone into the corresponding benzoquinone, which then undergoes a Diels-Alder reaction with a conjugate of cyclopentadiene and a peptide ligand. This in situ modification of the substrate gives a surface that promotes cell migration (see scheme).

Original languageEnglish (US)
Pages (from-to)1093-1096
Number of pages4
JournalAngewandte Chemie - International Edition
Volume40
Issue number6
DOIs
StatePublished - Mar 14 2001

Keywords

  • Bioorganic chemistry
  • Cell migration
  • Diels-Alder reaction
  • Monolayers
  • Oxidation

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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