TY - JOUR
T1 - Twelve-month outcomes of a randomized trial of a moderate-carbohydrate versus very low-carbohydrate diet in overweight adults with type 2 diabetes mellitus or prediabetes
AU - Saslow, Laura R.
AU - Daubenmier, Jennifer J.
AU - Moskowitz, Judith T.
AU - Kim, Sarah
AU - Murphy, Elizabeth J.
AU - Phinney, Stephen D.
AU - Ploutz-Snyder, Robert
AU - Goldman, Veronica
AU - Cox, Rachel M.
AU - Mason, Ashley E.
AU - Moran, Patricia
AU - Hecht, Frederick M.
N1 - Funding Information:
Thanks very much to Michael Hall for his help with running the in-person study, Carley Hauck for teaching the positive affect and mindful eating skills, and to our dedicated participants. The research was supported by a grant from the William K. Bowes, Jr. Foundation and the Mount Zion Health Fund. Laura Saslow and Ashley E. Mason were supported by National Institutes of Health grant T32AT003997 from the National Center for Complementary and Integrative Health. Laura Saslow was also supported by a K01 from the National Institute of Diabetes and Digestive and Kidney Diseases (DK107456). Ashley E. Mason was also supported by a K23 from the National Heart, Lung, and Blood Institute (HL133442). Judith Moskowitz was supported by National Institutes of Health grant K24 MH093225 from the National Institute of Mental Health. Frederick Hecht was supported by National Institutes of Health grant K24 AT007827 from National Center for Complementary and Integrative Health. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Funding Information:
Thanks very much to Michael Hall for his help with running the in-person study, Carley Hauck for teaching the positive affect and mindful eating skills, and to our dedicated participants. The research was supported by a grant from the William K. Bowes, Jr. Foundation and the Mount Zion Health Fund. Laura Saslow and Ashley E. Mason were supported by National Institutes of Health grant T32AT003997 from the National Center for Complementary and Integrative Health. Laura Saslow was also supported by a K01 from the National Institute of Diabetes and Digestive and Kidney Diseases (DK107456). Ashley E. Mason was also supported by a K23 from the National Heart, Lung, and Blood Institute (HL133442). Judith Moskowitz was supported by National Institutes of Health grant K24 MH093225 from the National Institute of Mental Health. Frederick Hecht was supported by National Institutes of Health grant K24 AT007827 from National Center for Complementary and Integrative Health. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript
Publisher Copyright:
© 2017 The Author(s).
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Dietary treatment is important in management of type 2 diabetes or prediabetes, but uncertainty exists about the optimal diet. We randomized adults (n = 34) with glycated hemoglobin (HbA1c) > 6.0% and elevated body weight (BMI > 25) to a very low-carbohydrate ketogenic (LCK) diet (n = 16) or a moderate-carbohydrate, calorie-restricted, low-fat (MCCR) diet (n = 18). All participants were encouraged to be physically active, get sufficient sleep, and practice behavioral adherence strategies based on positive affect and mindful eating. At 12 months, participants in the LCK group had greater reductions in HbA1c levels (estimated marginal mean (EMM) at baseline = 6.6%, at 12 mos = 6.1%) than participants in MCCR group (EMM at baseline = 6.9%, at 12 mos = 6.7%), p =.007. Participants in the LCK group lost more weight (EMM at baseline = 99.9 kg, at 12 mos = 92.0 kg) than participants in the MCCR group (EMM at baseline = 97.5 kg, at 12 mos = 95.8 kg), p <.001. The LCK participants experienced larger reductions in diabetes-related medication use; of participants who took sulfonylureas or dipeptidyl peptidase-4 inhibitors at baseline, 6/10 in the LCK group discontinued these medications compared with 0/6 in the MCCR group (p =.005). In a 12-month trial, adults with elevated HbA1c and body weight assigned to an LCK diet had greater reductions in HbA1c, lost more weight, and reduced more medications than those instructed to follow an MCCR diet.
AB - Dietary treatment is important in management of type 2 diabetes or prediabetes, but uncertainty exists about the optimal diet. We randomized adults (n = 34) with glycated hemoglobin (HbA1c) > 6.0% and elevated body weight (BMI > 25) to a very low-carbohydrate ketogenic (LCK) diet (n = 16) or a moderate-carbohydrate, calorie-restricted, low-fat (MCCR) diet (n = 18). All participants were encouraged to be physically active, get sufficient sleep, and practice behavioral adherence strategies based on positive affect and mindful eating. At 12 months, participants in the LCK group had greater reductions in HbA1c levels (estimated marginal mean (EMM) at baseline = 6.6%, at 12 mos = 6.1%) than participants in MCCR group (EMM at baseline = 6.9%, at 12 mos = 6.7%), p =.007. Participants in the LCK group lost more weight (EMM at baseline = 99.9 kg, at 12 mos = 92.0 kg) than participants in the MCCR group (EMM at baseline = 97.5 kg, at 12 mos = 95.8 kg), p <.001. The LCK participants experienced larger reductions in diabetes-related medication use; of participants who took sulfonylureas or dipeptidyl peptidase-4 inhibitors at baseline, 6/10 in the LCK group discontinued these medications compared with 0/6 in the MCCR group (p =.005). In a 12-month trial, adults with elevated HbA1c and body weight assigned to an LCK diet had greater reductions in HbA1c, lost more weight, and reduced more medications than those instructed to follow an MCCR diet.
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UR - http://www.scopus.com/inward/citedby.url?scp=85042378192&partnerID=8YFLogxK
U2 - 10.1038/s41387-017-0006-9
DO - 10.1038/s41387-017-0006-9
M3 - Article
C2 - 29269731
AN - SCOPUS:85042378192
SN - 2044-4052
VL - 7
JO - Nutrition and Diabetes
JF - Nutrition and Diabetes
IS - 12
M1 - 304
ER -
