Twitcher mice with only a single active galactosylceramide synthase gene exhibit clearly detectable but therapeutically minor phenotypic improvements

Keyphrases

• α-galactosylceramide (α-GalCer) 100%
• GalCer 100%
• Twitcher Mouse 100%
• Phenotypic Improvement 100%
• Genotype 20%
• Mouse Genetics 20%
• Gene Dosage 20%
• Meaningful Improvement 20%
• Genetic Disease 20%
• Gene-deficient Mice 20%
• Gene Level 20%
• Littermate 20%
• Statistical Significance 20%
• Degradative Enzymes 20%
• Enzyme Deficiency 20%
• Twitcher 20%
• Psychosine 20%

Biochemistry, Genetics and Molecular Biology

• Synthase 100%
• Twitcher Mouse 100%
• Genotyping 50%
• Gene Dosage 50%
• Degradative Enzyme 50%
• Genetic Disorder Treatment 50%
• Mouse Mutant 50%
• Lifespan 50%
• Body Weight 50%
• Single Drug Dose 50%
• Cross Breeding 50%

Neuroscience

• Synthetase 100%
• Galactosylceramide 100%
• Psychosine 20%
• Gene Dosage 20%