Two faces of vitamin e in the lung

Joan M. Cook-Mills*, Hiam Abdala-Valencia, Tina Hartert

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

Asthma and allergic lung disease occur as complex environmental and genetic interactions. Clinical studies of asthma indicate a number of protective dietary factors, such as vitamin E, on asthma risk. However, these studies have had seemingly conflicting outcomes. In this perspective, we discuss opposing regulatory effects of tocopherol isoforms of vitamin E, mechanisms for tocopherol isoform regulation of allergic lung inflammation, association of vitamin E isoforms with outcomes in clinical studies, and how the variation in global prevalence of asthma may be explained, at least in part, by vitamin E isoforms.

Original languageEnglish (US)
Pages (from-to)279-284
Number of pages6
JournalAmerican journal of respiratory and critical care medicine
Volume188
Issue number3
DOIs
StatePublished - Aug 1 2013

Keywords

  • A-tocopherol
  • Asthma
  • G-tocopherol
  • Human
  • Mouse

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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