Two novel members of the prolactin/growth hormone family are expressed in the mouse placenta

Jiandie Lin, Jason Poole, Daniel I.H. Linzer*

*Corresponding author for this work

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Two novel members of the mouse PRL/GH family have been identified through a search of an expressed sequence tag database. The encoded proteins do not appear to be homologs of other known members of this hormone family. One of these proteins, designated PRL-like protein E (PLP-E), is predicted to be synthesized as a precursor of 265 amino acids, modified by N-linked glycosylation, and secreted as a mature glycoprotein of 236 residues. The second clone encodes a protein of 253 residues with consensus sites for N- linked glycosylation; the secreted form of the protein, designated PRL-like protein F (PLP-F), is predicted to be 223 amino acids in length. Both of these messenger RNAs are expressed specifically in the placenta, with peak levels of PLP-E on days 10-12 and of PLP-F on days 14-16. Expression of PLP- E is restricted to the trophoblast giant cells whereas PLP-F is synthesized only in the spongiotrophoblasts. The genes for both of these proteins map to a 700-kilobase region of mouse chromosome 13 that includes other members of the PRL/GH family.

Original languageEnglish (US)
Pages (from-to)5535-5540
Number of pages6
JournalEndocrinology
Volume138
Issue number12
DOIs
StatePublished - 1997

ASJC Scopus subject areas

  • Endocrinology

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