Two sites of synaptic integration: Relevant for learning?

Konrad Kording*, Peter Konig

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Electrophysiological research on the properties of the apical dendrites of cortical deep layer pyramidal cells suggests that it acts, in addition to the soma, as a second site of synaptic integration. Each site integrates input from a subset of synapses and is able to generate regenerative potentials. The sites exchange information in stereotyped ways: Signals from the soma are transmitted to the apical dendrite via actively back-propagating dendritic action potentials. Slow regenerative calcium spikes transmit information from the apical dendrite to the soma. These calcium spikes lead to a strong and prolonged depolarization of the cell generating a burst of action potentials. This paper analyzes how the system learns if these calcium spikes trigger hebbian learning at active synapses. A cell is now described by two main variables the mean activity and the mean potential at the apical dendrite with the first variable defining the input to cells downstream and the latter what the cell learns. A system results where neurons learn to respond to those features that are correlated with activity on the higher layer, this property is similar to maximizing the mutual information between input and higher areas. Furthermore it learns invariances exploiting a spatial smoothness criterion.

Original languageEnglish (US)
Title of host publicationProceedings of the International Joint Conference on Neural Networks
PublisherIEEE
Pages479-484
Number of pages6
Volume4
StatePublished - Jan 1 2000
EventInternational Joint Conference on Neural Networks (IJCNN'2000) - Como, Italy
Duration: Jul 24 2000Jul 27 2000

Other

OtherInternational Joint Conference on Neural Networks (IJCNN'2000)
CityComo, Italy
Period7/24/007/27/00

ASJC Scopus subject areas

  • Software

Fingerprint Dive into the research topics of 'Two sites of synaptic integration: Relevant for learning?'. Together they form a unique fingerprint.

  • Cite this

    Kording, K., & Konig, P. (2000). Two sites of synaptic integration: Relevant for learning? In Proceedings of the International Joint Conference on Neural Networks (Vol. 4, pp. 479-484). IEEE.