Two types of A-current differing in voltage-dependence are expressed by neurons of the rat neostriatum

D. James Surmeier; J. Bargas; S. T. Kitai

doi:10.1016/0304-3940(89)90122-5

Two types of A-current differing in voltage-dependence are expressed by neurons of the rat neostriatum

D. James Surmeier^*, J. Bargas, S. T. Kitai

^*Corresponding author for this work

Physiology

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Transient potassium currents of the A type are thought to be important in a number of physiological processes of excitable cells, including spike repolarization and synaptic integration. This functional diversity may reflect the contribution of distinct subtypes of A channel to cellular behavior. Using the whole-cell variant of the patch clamp technique, we have found that two types of A-current are expressed in rat neostriatal neurons, one that is similar to previous descriptions in mammals and a second that is activated at considerably more depolarized potentials.

Original language	English (US)
Pages (from-to)	331-337
Number of pages	7
Journal	Neuroscience Letters
Volume	103
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(89)90122-5
State	Published - Sep 11 1989

Keywords

A-current
Neostriatum
Rat
Voltage-dependence
Whole-cell voltage-clamp

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0304-3940(89)90122-5

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title = "Two types of A-current differing in voltage-dependence are expressed by neurons of the rat neostriatum",

abstract = "Transient potassium currents of the A type are thought to be important in a number of physiological processes of excitable cells, including spike repolarization and synaptic integration. This functional diversity may reflect the contribution of distinct subtypes of A channel to cellular behavior. Using the whole-cell variant of the patch clamp technique, we have found that two types of A-current are expressed in rat neostriatal neurons, one that is similar to previous descriptions in mammals and a second that is activated at considerably more depolarized potentials.",

keywords = "A-current, Neostriatum, Rat, Voltage-dependence, Whole-cell voltage-clamp",

author = "{James Surmeier}, D. and J. Bargas and Kitai, {S. T.}",

note = "Funding Information: We thank Drs. W.E. Crill, P.C. Schwindt, W,J. Spain, E.W. MeCleskey, C.J. Wilson, R.C. Foehring and M.R. Park for their critical reading of the manuscript, This work was supported by P.H.S. Grant NS 20702 to S.T.K. NS 26473 to S,T.K. and D.J.S. and a grant from the Huntington's Disease Society of America, Inc, to D.AS.",

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T1 - Two types of A-current differing in voltage-dependence are expressed by neurons of the rat neostriatum

AU - James Surmeier, D.

AU - Bargas, J.

AU - Kitai, S. T.

N1 - Funding Information: We thank Drs. W.E. Crill, P.C. Schwindt, W,J. Spain, E.W. MeCleskey, C.J. Wilson, R.C. Foehring and M.R. Park for their critical reading of the manuscript, This work was supported by P.H.S. Grant NS 20702 to S.T.K. NS 26473 to S,T.K. and D.J.S. and a grant from the Huntington's Disease Society of America, Inc, to D.AS.

PY - 1989/9/11

Y1 - 1989/9/11

N2 - Transient potassium currents of the A type are thought to be important in a number of physiological processes of excitable cells, including spike repolarization and synaptic integration. This functional diversity may reflect the contribution of distinct subtypes of A channel to cellular behavior. Using the whole-cell variant of the patch clamp technique, we have found that two types of A-current are expressed in rat neostriatal neurons, one that is similar to previous descriptions in mammals and a second that is activated at considerably more depolarized potentials.

AB - Transient potassium currents of the A type are thought to be important in a number of physiological processes of excitable cells, including spike repolarization and synaptic integration. This functional diversity may reflect the contribution of distinct subtypes of A channel to cellular behavior. Using the whole-cell variant of the patch clamp technique, we have found that two types of A-current are expressed in rat neostriatal neurons, one that is similar to previous descriptions in mammals and a second that is activated at considerably more depolarized potentials.

KW - A-current

KW - Neostriatum

KW - Rat

KW - Voltage-dependence

KW - Whole-cell voltage-clamp

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JF - Neuroscience Letters

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ER -

Two types of A-current differing in voltage-dependence are expressed by neurons of the rat neostriatum

Abstract

Keywords

ASJC Scopus subject areas

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