Two types of A-current differing in voltage-dependence are expressed by neurons of the rat neostriatum

D. James Surmeier*, J. Bargas, S. T. Kitai

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Transient potassium currents of the A type are thought to be important in a number of physiological processes of excitable cells, including spike repolarization and synaptic integration. This functional diversity may reflect the contribution of distinct subtypes of A channel to cellular behavior. Using the whole-cell variant of the patch clamp technique, we have found that two types of A-current are expressed in rat neostriatal neurons, one that is similar to previous descriptions in mammals and a second that is activated at considerably more depolarized potentials.

Original languageEnglish (US)
Pages (from-to)331-337
Number of pages7
JournalNeuroscience Letters
Volume103
Issue number3
DOIs
StatePublished - Sep 11 1989

Keywords

  • A-current
  • Neostriatum
  • Rat
  • Voltage-dependence
  • Whole-cell voltage-clamp

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Two types of A-current differing in voltage-dependence are expressed by neurons of the rat neostriatum'. Together they form a unique fingerprint.

Cite this