TY - JOUR
T1 - Two-Year Impact of Prevention Programs on Adolescent Depression
T2 - an Integrative Data Analysis Approach
AU - Brown, C. Hendricks
AU - Brincks, Ahnalee
AU - Huang, Shi
AU - Perrino, Tatiana
AU - Cruden, Gracelyn
AU - Pantin, Hilda
AU - Howe, George
AU - Young, Jami F.
AU - Beardslee, William
AU - Montag, Samantha
AU - Sandler, Irwin
N1 - Funding Information:
Funding Funding for this project was by NIMH R01MH040859 (Collaborative Synthesis for Adolescent Depression Trials, Brown PI) and the following grants for the specific trials: Garber, Brent, Beardslee, Clarke et al.—NIMH MH064735, MH064503, MH064717; Gillham et al.— NIMH MH52270; Garber et al.—William T. Grant Foundation 961730; Dishion et al.—NIDA DA07031 and DA13773; Szapocznik et al.— NIMH MH61143; Pantin et al.—NIDA DA017462; Prado et al.—NIDA DA025894; Prado et al.—CDC U01PS000671; Stormshak et al.—NIDA DA018374; Sandler et al.—NIMH MH49155; Wolchik et al.—NIMH MH068685; Young et al.—NARSAD; Spoth et al.—NIDA DA 007029; Clarke et al.—NIMH MH 48118; Young et al.—NIMH MH071320; Beardslee et al.—NIMH MH48696; VanVoorhees et al.—NIMH MH072918; and Gonzales et al.—NIMH MH64707.
Funding Information:
We gratefully acknowledge the National Institute of Mental Health Collaborative Synthesis for Adolescent Depression Trials Study Team, comprising our many colleagues who generously provided their data to be used in this study, obtained access to key datasets, reviewed coding decisions, provided substantive or methodologic recommendations, and reviewed this manuscript. We also thank NIMH for their support through grant number R01MH040859 (Collaborative Synthesis for Adolescent Depression Trials, Brown PI), and the following grants: Garber, Brent, Beardslee, Clarke et al.?NIMH MH064735, MH064503, MH064717; Gillham et al.?NIMH MH52270; Garber et al.?William T. Grant Foundation 961730; Dishion et al.?NIDA DA07031 and DA13773; Szapocznik et al.?NIMH MH61143; Pantin et al.?NIDA DA017462; Prado et al.?NIDA DA025894; Prado et al.?CDC U01PS000671; Stormshak et al.?NIDA DA018374; Sandler et al.?NIMH MH49155; Wolchik et al.?NIMH MH068685; Young et al.?NARSAD; Spoth et al.?NIDA DA 007029; Clarke et al.?NIMH MH 48118; Young et al.?NIMH MH071320; Beardslee et al.?NIMH MH48696; VanVoorhees et al.?NIMH MH072918; and Gonzales et al.?NIMH MH64707. The content of this paper is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies or that of our collaborators who provided access to their data. Funding for this project was by NIMH R01MH040859 (Collaborative Synthesis for Adolescent Depression Trials, Brown PI) and the following grants for the specific trials: Garber, Brent, Beardslee, Clarke et al.?NIMH MH064735, MH064503, MH064717; Gillham et al.?NIMH MH52270; Garber et al.?William T. Grant Foundation 961730; Dishion et al.?NIDA DA07031 and DA13773; Szapocznik et al.?NIMH MH61143; Pantin et al.?NIDA DA017462; Prado et al.?NIDA DA025894; Prado et al.?CDC U01PS000671; Stormshak et al.?NIDA DA018374; Sandler et al.?NIMH MH49155; Wolchik et al.?NIMH MH068685; Young et al.?NARSAD; Spoth et al.?NIDA DA 007029; Clarke et al.?NIMH MH 48118; Young et al.?NIMH MH071320; Beardslee et al.?NIMH MH48696; VanVoorhees et al.?NIMH MH072918; and Gonzales et al.?NIMH MH64707. CHB was supported as a consultant on one of these projects (New Beginnings) and received funding support on the Familias Unidas trials, as did Huang. Young, Sandler, Pantin, and Beardslee directed their own trials that are included in this synthesis. Brincks, Perrino, and Cruden were colleagues of Pantin. All the trial directors were consulted on codings for their trials and were offered an opportunity to provide comments before this paper was submitted.
Funding Information:
Institute of Mental Health Collaborative Synthesis for Adolescent Depression Trials Study Team, comprising our many colleagues who generously provided their data to be used in this study, obtained access to key datasets, reviewed coding decisions, provided substantive or methodologic recommendations, and reviewed this manuscript. We also thank NIMH for their support through grant number R01MH040859 (Collaborative Synthesis for Adolescent Depression Trials, Brown PI), and the following grants: Garber, Brent, Beardslee, Clarke et al.—NIMH MH064735, MH064503, MH064717; Gillham et al.—NIMH MH52270; Garber et al.—William T. Grant Foundation 961730; Dishion et al.—NIDA DA07031 and DA13773; Szapocznik et al.—NIMH MH61143; Pantin et al.—NIDA DA017462; Prado et al.—NIDA DA025894; Prado et al.—CDC U01PS000671; Stormshak et al.—NIDA DA018374; Sandler et al.—NIMH MH49155; Wolchik et al.—NIMH MH068685; Young et al.— NARSAD; Spoth et al.—NIDA DA 007029; Clarke et al.— NIMH MH 48118; Young et al.—NIMH MH071320; Beardslee et al.—NIMH MH48696; VanVoorhees et al.—NIMH MH072918; and Gonzales et al.—NIMH MH64707. The content of this paper is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies or that of our collaborators who provided access to their data.
Publisher Copyright:
© 2016, Society for Prevention Research.
PY - 2018/2/1
Y1 - 2018/2/1
N2 - This paper presents the first findings of an integrative data analysis of individual-level data from 19 adolescent depression prevention trials (n = 5210) involving nine distinct interventions across 2 years post-randomization. In separate papers, several interventions have been found to decrease the risk of depressive disorders or elevated depressive/internalizing symptoms among youth. One type of intervention specifically targets youth without a depressive disorder who are at risk due to elevated depressive symptoms and/or having a parent with a depressive disorder. A second type of intervention targets two broad domains: prevention of problem behaviors, which we define as drug use/abuse, sexual risk behaviors, conduct disorder, or other externalizing problems, and general mental health. Most of these latter interventions improve parenting or family factors. We examined the shared and unique effects of these interventions by level of baseline youth depressive symptoms, sociodemographic characteristics of the youth (age, sex, parent education, and family income), type of intervention, and mode of intervention delivery to the youth, parent(s), or both. We harmonized eight different measures of depression utilized across these trials and used growth models to evaluate intervention impact over 2 years. We found a significant overall effect of these interventions on reducing depressive symptoms over 2 years and a stronger impact among those interventions that targeted depression specifically rather than problem behaviors or general mental health, especially when baseline symptoms were high. Implications for improving population-level impact are discussed.
AB - This paper presents the first findings of an integrative data analysis of individual-level data from 19 adolescent depression prevention trials (n = 5210) involving nine distinct interventions across 2 years post-randomization. In separate papers, several interventions have been found to decrease the risk of depressive disorders or elevated depressive/internalizing symptoms among youth. One type of intervention specifically targets youth without a depressive disorder who are at risk due to elevated depressive symptoms and/or having a parent with a depressive disorder. A second type of intervention targets two broad domains: prevention of problem behaviors, which we define as drug use/abuse, sexual risk behaviors, conduct disorder, or other externalizing problems, and general mental health. Most of these latter interventions improve parenting or family factors. We examined the shared and unique effects of these interventions by level of baseline youth depressive symptoms, sociodemographic characteristics of the youth (age, sex, parent education, and family income), type of intervention, and mode of intervention delivery to the youth, parent(s), or both. We harmonized eight different measures of depression utilized across these trials and used growth models to evaluate intervention impact over 2 years. We found a significant overall effect of these interventions on reducing depressive symptoms over 2 years and a stronger impact among those interventions that targeted depression specifically rather than problem behaviors or general mental health, especially when baseline symptoms were high. Implications for improving population-level impact are discussed.
KW - Cognitive behavioral therapy
KW - Data synthesis
KW - Growth mixture modeling
KW - Growth modeling
KW - Interpersonal therapy
KW - Parenting interventions
KW - Person-level meta-analysis
UR - http://www.scopus.com/inward/record.url?scp=85007256414&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85007256414&partnerID=8YFLogxK
U2 - 10.1007/s11121-016-0737-1
DO - 10.1007/s11121-016-0737-1
M3 - Article
C2 - 28013420
AN - SCOPUS:85007256414
SN - 1389-4986
VL - 19
SP - 74
EP - 94
JO - Prevention Science
JF - Prevention Science
ER -
