Twofold unsymmetrical C-H functionalization of PyrDipSi-substituted arenes: A general method for the synthesis of substituted meta-halophenols

Dhruba Sarkar; Ferdinand S. Melkonyan; Anton V. Gulevich; Vladimir Gevorgyan

doi:10.1002/anie.201304884

Twofold unsymmetrical C-H functionalization of PyrDipSi-substituted arenes: A general method for the synthesis of substituted meta-halophenols

Dhruba Sarkar, Ferdinand S. Melkonyan, Anton V. Gulevich, Vladimir Gevorgyan^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

84 Scopus citations

Abstract

And the world is your oyster Sequential halogenation/oxygenation reactions of 2-diisopropylsilylpyrimidine-substituted arenes provide a general and efficient synthesis of substituted meta-halophenols from simple aryl iodides (see scheme; Piv=pivaloyl). The products are poised to undergo diverse C-C, C-N, and C-O bond-forming reactions that enable the transformation of their framework and the introduction of valuable functionalities.

Original language	English (US)
Pages (from-to)	10800-10804
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	41
DOIs	https://doi.org/10.1002/anie.201304884
State	Published - Oct 4 2013

Keywords

C-H activation
cross-coupling
halogenation
oxygenation
palladium

ASJC Scopus subject areas

General Chemistry
Catalysis

Access to Document

10.1002/anie.201304884

Cite this

@article{9bef4590b6a344aaa79e7a5f0b6b2292,

title = "Twofold unsymmetrical C-H functionalization of PyrDipSi-substituted arenes: A general method for the synthesis of substituted meta-halophenols",

abstract = "And the world is your oyster Sequential halogenation/oxygenation reactions of 2-diisopropylsilylpyrimidine-substituted arenes provide a general and efficient synthesis of substituted meta-halophenols from simple aryl iodides (see scheme; Piv=pivaloyl). The products are poised to undergo diverse C-C, C-N, and C-O bond-forming reactions that enable the transformation of their framework and the introduction of valuable functionalities.",

keywords = "C-H activation, cross-coupling, halogenation, oxygenation, palladium",

author = "Dhruba Sarkar and Melkonyan, {Ferdinand S.} and Gulevich, {Anton V.} and Vladimir Gevorgyan",

year = "2013",

month = oct,

day = "4",

doi = "10.1002/anie.201304884",

language = "English (US)",

volume = "52",

pages = "10800--10804",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "41",

}

Twofold unsymmetrical C-H functionalization of PyrDipSi-substituted arenes: A general method for the synthesis of substituted meta-halophenols. / Sarkar, Dhruba; Melkonyan, Ferdinand S.; Gulevich, Anton V. et al.
In: Angewandte Chemie - International Edition, Vol. 52, No. 41, 04.10.2013, p. 10800-10804.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Twofold unsymmetrical C-H functionalization of PyrDipSi-substituted arenes

T2 - A general method for the synthesis of substituted meta-halophenols

AU - Sarkar, Dhruba

AU - Melkonyan, Ferdinand S.

AU - Gulevich, Anton V.

AU - Gevorgyan, Vladimir

PY - 2013/10/4

Y1 - 2013/10/4

N2 - And the world is your oyster Sequential halogenation/oxygenation reactions of 2-diisopropylsilylpyrimidine-substituted arenes provide a general and efficient synthesis of substituted meta-halophenols from simple aryl iodides (see scheme; Piv=pivaloyl). The products are poised to undergo diverse C-C, C-N, and C-O bond-forming reactions that enable the transformation of their framework and the introduction of valuable functionalities.

AB - And the world is your oyster Sequential halogenation/oxygenation reactions of 2-diisopropylsilylpyrimidine-substituted arenes provide a general and efficient synthesis of substituted meta-halophenols from simple aryl iodides (see scheme; Piv=pivaloyl). The products are poised to undergo diverse C-C, C-N, and C-O bond-forming reactions that enable the transformation of their framework and the introduction of valuable functionalities.

KW - C-H activation

KW - cross-coupling

KW - halogenation

KW - oxygenation

KW - palladium

UR - http://www.scopus.com/inward/record.url?scp=84885118711&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84885118711&partnerID=8YFLogxK

U2 - 10.1002/anie.201304884

DO - 10.1002/anie.201304884

M3 - Article

C2 - 24038769

AN - SCOPUS:84885118711

SN - 1433-7851

VL - 52

SP - 10800

EP - 10804

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 41

ER -

Twofold unsymmetrical C-H functionalization of PyrDipSi-substituted arenes: A general method for the synthesis of substituted meta-halophenols

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this