Type 2 Diabetes Mellitus as a Risk Factor for Alzheimer's Disease

Jacqueline A. Bonds*, Peter C. Hart, Richard D. Minshall, Orly Lazarov, Jacob M. Haus, Marcelo G. Bonini

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Type 2 diabetes mellitus (T2DM) is an acknowledged risk factor for the development of Alzheimer's disease (AD). However, molecular mechanisms linking these disorders remain poorly defined. This chapter will review recent advancements in the understanding of the etiologic causes of AD occurring in a subgroup of diabetic patients based on studies using a variety of animal models of insulin resistance, and T2DM. We will also focus on vascular deterioration and defective insulin signaling in the brain as primary causes of molecular, vascular, and neuronal changes that translate into cognitive decline, memory loss, and other features characteristic of AD.

Original languageEnglish (US)
Title of host publicationGenes, Environment and Alzheimer's Disease
PublisherElsevier Inc
Pages387-413
Number of pages27
ISBN (Print)9780128028513
DOIs
StatePublished - 2016
Externally publishedYes

Keywords

  • Diabetes
  • Endothelial cells
  • Inflammation
  • Insulin
  • Interleukin
  • Tumor necrosis factor
  • Vasculature

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

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