Type 2 diabetes mellitus (T2DM) is an acknowledged risk factor for the development of Alzheimer's disease (AD). However, molecular mechanisms linking these disorders remain poorly defined. This chapter will review recent advancements in the understanding of the etiologic causes of AD occurring in a subgroup of diabetic patients based on studies using a variety of animal models of insulin resistance, and T2DM. We will also focus on vascular deterioration and defective insulin signaling in the brain as primary causes of molecular, vascular, and neuronal changes that translate into cognitive decline, memory loss, and other features characteristic of AD.
|Original language||English (US)|
|Title of host publication||Genes, Environment and Alzheimer's Disease|
|Number of pages||27|
|State||Published - 2016|
- Endothelial cells
- Tumor necrosis factor
ASJC Scopus subject areas