Type 2 Diabetes Mellitus as a Risk Factor for Alzheimer's Disease

Jacqueline A. Bonds; Peter C. Hart; Richard D. Minshall; Orly Lazarov; Jacob M. Haus; Marcelo G. Bonini

doi:10.1016/B978-0-12-802851-3.00013-9

Type 2 Diabetes Mellitus as a Risk Factor for Alzheimer's Disease

Jacqueline A. Bonds^*, Peter C. Hart, Richard D. Minshall, Orly Lazarov, Jacob M. Haus, Marcelo G. Bonini

^*Corresponding author for this work

Medicine, Hematology Oncology Division

Research output: Chapter in Book/Report/Conference proceeding › Chapter

4 Scopus citations

Abstract

Type 2 diabetes mellitus (T2DM) is an acknowledged risk factor for the development of Alzheimer's disease (AD). However, molecular mechanisms linking these disorders remain poorly defined. This chapter will review recent advancements in the understanding of the etiologic causes of AD occurring in a subgroup of diabetic patients based on studies using a variety of animal models of insulin resistance, and T2DM. We will also focus on vascular deterioration and defective insulin signaling in the brain as primary causes of molecular, vascular, and neuronal changes that translate into cognitive decline, memory loss, and other features characteristic of AD.

Original language	English (US)
Title of host publication	Genes, Environment and Alzheimer's Disease
Publisher	Elsevier Inc
Pages	387-413
Number of pages	27
ISBN (Print)	9780128028513
DOIs	https://doi.org/10.1016/B978-0-12-802851-3.00013-9
State	Published - 2016

Keywords

Diabetes
Endothelial cells
Inflammation
Insulin
Interleukin
Tumor necrosis factor
Vasculature

ASJC Scopus subject areas

General Medicine
General Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/B978-0-12-802851-3.00013-9

Cite this

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title = "Type 2 Diabetes Mellitus as a Risk Factor for Alzheimer's Disease",

abstract = "Type 2 diabetes mellitus (T2DM) is an acknowledged risk factor for the development of Alzheimer's disease (AD). However, molecular mechanisms linking these disorders remain poorly defined. This chapter will review recent advancements in the understanding of the etiologic causes of AD occurring in a subgroup of diabetic patients based on studies using a variety of animal models of insulin resistance, and T2DM. We will also focus on vascular deterioration and defective insulin signaling in the brain as primary causes of molecular, vascular, and neuronal changes that translate into cognitive decline, memory loss, and other features characteristic of AD.",

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AU - Bonds, Jacqueline A.

AU - Hart, Peter C.

AU - Minshall, Richard D.

AU - Lazarov, Orly

AU - Haus, Jacob M.

AU - Bonini, Marcelo G.

PY - 2016

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AB - Type 2 diabetes mellitus (T2DM) is an acknowledged risk factor for the development of Alzheimer's disease (AD). However, molecular mechanisms linking these disorders remain poorly defined. This chapter will review recent advancements in the understanding of the etiologic causes of AD occurring in a subgroup of diabetic patients based on studies using a variety of animal models of insulin resistance, and T2DM. We will also focus on vascular deterioration and defective insulin signaling in the brain as primary causes of molecular, vascular, and neuronal changes that translate into cognitive decline, memory loss, and other features characteristic of AD.

KW - Diabetes

KW - Endothelial cells

KW - Inflammation

KW - Insulin

KW - Interleukin

KW - Tumor necrosis factor

KW - Vasculature

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M3 - Chapter

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BT - Genes, Environment and Alzheimer's Disease

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ER -

Type 2 Diabetes Mellitus as a Risk Factor for Alzheimer's Disease

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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