Type i and ii interferons in the anti-tumor immune response

Sarah E. Fenton, Diana Saleiro, Leonidas C. Platanias*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

The interferons (IFNs) are essential components of the immune response against infec-tions and malignancies. IFNs are potent promoters of the anti-tumor response, but there is also evidence that feedback mechanisms regulated by IFNs negatively control immune responses to avoid hyper-activation and limit inflammation. This balance of responses plays an important role in cancer surveillance, immunoediting and response to anticancer therapeutic approaches. Here we review the roles of both type I and type II IFNs on the control of the immune response against malignancies in the context of effects on both malignant cells and cells of the immune system in the tumor microenvironment.

Original languageEnglish (US)
Article number1037
Pages (from-to)1-19
Number of pages19
JournalCancers
Volume13
Issue number5
DOIs
StatePublished - Mar 1 2021

Keywords

  • Cancer
  • Cancer immunoediting
  • Dendritic cell
  • Interferons
  • Macrophage
  • T cell

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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