Type II diabetes mellitus is associated with decreased measures of lung function in a clinical setting

Oana L. Klein, David Meltzer, Mercedes Carnethon, Jerry A. Krishnan

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Aims: Type II diabetes mellitus has been associated with reduced forced expiratory volume in first second (FEV1) and forced vital capacity (FVC). We investigated if this relationship is maintained in a clinical setting, independent of respiratory infections and heart failure. Methods: Pulmonary function tests and discharge summaries of 639 adults 18-80 years of age, of different races/ethnicities, seen at an urban hospital during a two years period were reviewed. After selection of patients based on inclusion/exclusion criteria, 286 patients were included in our analysis. Using multivariable linear regression we examined cross-sectional differences of FEV1 and FVC between patients with and without diabetes, adjusting for age, sex, race/ethnicity, BMI, smoking and respiratory symptoms. Results: Patients with diabetes were older (63 ± 1 vs. 56 ± 1), more likely to be African-Americans (30% vs. 25%) and Hispanics (40% vs. 31%), have respiratory symptoms (79% vs. 68%), and a higher BMI (34.2 ± 1.0 vs. 30.1 ± 0.6), compared to patients without diabetes. The distribution of women and smoking among the two groups were similar. The mean unadjusted percent predicted values of FEV1 and FVC in patients with diabetes were lower than in those without diabetes, and remained significantly reduced after adjustment (77.3 ± 0.5 vs. 82.0 ± 0.3, p < 0.01 for FEV1 and 73.8 ± 0.6 vs. 82.8 ± 0.3, p < 0.01 for FVC, respectively). Conclusions: In a clinical setting, patients with diabetes have decreased lung function compared to their non-diabetic counterparts, independent of respiratory infections and heart failure.

Original languageEnglish (US)
Pages (from-to)1095-1098
Number of pages4
JournalRespiratory Medicine
Volume105
Issue number7
DOIs
StatePublished - Jul 2011

Keywords

  • Diabetes
  • Forced expiratory volume in first second (FEV )
  • Forced vital capacity (FVC)
  • Heart failure
  • Lung function

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Fingerprint Dive into the research topics of 'Type II diabetes mellitus is associated with decreased measures of lung function in a clinical setting'. Together they form a unique fingerprint.

Cite this