Type II natural killer T cells foster the antitumor activity of CpG-oligodeoxynucleotides

Jie Zhao, Sreya Bagchi, Chyung Ru Wang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Type II natural killer T (NKT) cells in cancer immunity are typically associated with suppression of tumor immunosurveillance through secretion of IL-13. We previously demonstrated that CpG oligonucleotide therapy activated Type II NKT cells to produce T helper type 1 (Th1) rather than T helper type 2 (Th2) cytokines. This cytokine skewing may manifest in Type II NKT cell antitumor properties in an immunotherapeutic setting.

Original languageEnglish (US)
Article numbere28977
JournalOncoImmunology
Volume3
Issue number5
DOIs
StatePublished - 2014

Keywords

  • CD1
  • Immunotherapy
  • NKT cells
  • Tumor immunity

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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