Type II natural killer T cells foster the antitumor activity of CpG-oligodeoxynucleotides

Jie Zhao; Sreya Bagchi; Chyung Ru Wang

doi:10.4161/onci.28977

Type II natural killer T cells foster the antitumor activity of CpG-oligodeoxynucleotides

Jie Zhao, Sreya Bagchi, Chyung Ru Wang^*

^*Corresponding author for this work

Microbiology-Immunology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Type II natural killer T (NKT) cells in cancer immunity are typically associated with suppression of tumor immunosurveillance through secretion of IL-13. We previously demonstrated that CpG oligonucleotide therapy activated Type II NKT cells to produce T helper type 1 (Th1) rather than T helper type 2 (Th2) cytokines. This cytokine skewing may manifest in Type II NKT cell antitumor properties in an immunotherapeutic setting.

Original language	English (US)
Article number	e28977
Journal	OncoImmunology
Volume	3
Issue number	5
DOIs	https://doi.org/10.4161/onci.28977
State	Published - 2014

Keywords

CD1
Immunotherapy
NKT cells
Tumor immunity

ASJC Scopus subject areas

Oncology
Immunology and Allergy
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4161/onci.28977

Cite this

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abstract = "Type II natural killer T (NKT) cells in cancer immunity are typically associated with suppression of tumor immunosurveillance through secretion of IL-13. We previously demonstrated that CpG oligonucleotide therapy activated Type II NKT cells to produce T helper type 1 (Th1) rather than T helper type 2 (Th2) cytokines. This cytokine skewing may manifest in Type II NKT cell antitumor properties in an immunotherapeutic setting.",

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AU - Zhao, Jie

AU - Bagchi, Sreya

AU - Wang, Chyung Ru

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N2 - Type II natural killer T (NKT) cells in cancer immunity are typically associated with suppression of tumor immunosurveillance through secretion of IL-13. We previously demonstrated that CpG oligonucleotide therapy activated Type II NKT cells to produce T helper type 1 (Th1) rather than T helper type 2 (Th2) cytokines. This cytokine skewing may manifest in Type II NKT cell antitumor properties in an immunotherapeutic setting.

AB - Type II natural killer T (NKT) cells in cancer immunity are typically associated with suppression of tumor immunosurveillance through secretion of IL-13. We previously demonstrated that CpG oligonucleotide therapy activated Type II NKT cells to produce T helper type 1 (Th1) rather than T helper type 2 (Th2) cytokines. This cytokine skewing may manifest in Type II NKT cell antitumor properties in an immunotherapeutic setting.

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KW - Immunotherapy

KW - NKT cells

KW - Tumor immunity

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Type II natural killer T cells foster the antitumor activity of CpG-oligodeoxynucleotides

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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