TY - JOUR
T1 - Type II secretion
T2 - A protein secretion system for all seasons
AU - Cianciotto, Nicholas P.
N1 - Funding Information:
I acknowledge past and present laboratory members who have contributed so much to the study of type II secretion in Legionella . I also thank Ombeline Rossier for review of the manuscript, Hank Seifert for discussions of BLAST results, and Nancy Elizabeth Freitag for helpful insights into taxonomy. This work was supported by NIH grant AI43987.
PY - 2005/12
Y1 - 2005/12
N2 - In Gram-negative bacteria, type II secretion (T2S) is one of five protein secretion systems that permit the export of proteins from within the bacterial cell to the extracellular milieu and/or into target host cells. An analysis of numerous sequenced genomes now reveals that T2S genes are common, but by no means universal, in Gram-negative bacteria. Recent functional studies indicate that T2S can promote the virulence of human, animal and plant pathogens, as well as the physiology of various environmental bacteria. Thus, it is an opportune time to highlight the new and different ways in which T2S serves bacterial function.
AB - In Gram-negative bacteria, type II secretion (T2S) is one of five protein secretion systems that permit the export of proteins from within the bacterial cell to the extracellular milieu and/or into target host cells. An analysis of numerous sequenced genomes now reveals that T2S genes are common, but by no means universal, in Gram-negative bacteria. Recent functional studies indicate that T2S can promote the virulence of human, animal and plant pathogens, as well as the physiology of various environmental bacteria. Thus, it is an opportune time to highlight the new and different ways in which T2S serves bacterial function.
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U2 - 10.1016/j.tim.2005.09.005
DO - 10.1016/j.tim.2005.09.005
M3 - Review article
C2 - 16216510
AN - SCOPUS:27844506497
SN - 0966-842X
VL - 13
SP - 581
EP - 588
JO - Trends in Microbiology
JF - Trends in Microbiology
IS - 12
ER -
