Ubiquilin-1 overexpression increases the lifespan and delays accumulation of huntingtin aggregates in the R6/2 mouse model of huntington's disease

INIS

• nervous system diseases 62%
• mice 50%
• levels 37%
• proteins 37%
• toxicity 37%
• animals 25%
• transgenic mice 25%
• hippocampus 25%
• expansion 25%
• clearance 25%
• humans 12%
• diseases 12%
• pathology 12%
• brain 12%
• neurons 12%
• mutants 12%
• reduction 12%
• promoters 12%
• accumulation 12%
• symptoms 12%
• motors 12%
• inclusions 12%
• aggregation 12%
• restoration 12%
• progeny 12%
• endoplasmic reticulum 12%
• invertebrates 12%

Biochemistry, Genetics and Molecular Biology

• Huntingtin 75%
• Western Blot 50%
• Mouse 37%
• Clearance 25%
• Transgenic Mouse 25%
• Lifespan 25%
• Animal 25%
• Transgenics 25%
• Mouse Model 12%
• Autophagy 12%
• Promoter Region 12%
• Proteasome 12%
• Mammalian Cell 12%
• Polyglutamine Tract 12%
• Progeny 12%
• Endoplasmic Reticulum Stress 12%
• Reduction (Chemistry) 12%
• Mutant 12%
• Invertebrate Model 12%

Neuroscience

• Huntingtin 100%
• Huntington's Disease 62%
• Hippocampus 25%
• Neurodegeneration 12%
• Striatum 12%
• Immunohistochemistry 12%
• Promoter Region 12%
• Autophagy 12%
• Proteasome 12%
• Endoplasmic Reticulum Stress 12%
• Protein 12%
• Neuron 12%
• Brain 12%
• Neurodegenerative Disorder 12%