Ubiquitin-proteasome signaling in lung injury

Natalia D. Magnani; Laura A. Dada; Jacob I. Sznajder

doi:10.1016/j.trsl.2018.04.003

Ubiquitin-proteasome signaling in lung injury

Natalia D. Magnani, Laura A. Dada, Jacob I. Sznajder^*

^*Corresponding author for this work

Medicine, Pulmonary Division

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

Cell homeostasis requires precise coordination of cellular proteins function. Ubiquitination is a post-translational modification that modulates protein half-life and function and is tightly regulated by ubiquitin E3 ligases and deubiquitinating enzymes. Lung injury can progress to acute respiratory distress syndrome that is characterized by an inflammatory response and disruption of the alveolocapillary barrier resulting in alveolar edema accumulation and hypoxemia. Ubiquitination plays an important role in the pathobiology of acute lung injury as it regulates the proteins modulating the alveolocapillary barrier and the inflammatory response. Better understanding of the signaling pathways regulated by ubiquitination may lead to novel therapeutic approaches by targeting specific elements of the ubiquitination pathways.

Original language	English (US)
Pages (from-to)	29-39
Number of pages	11
Journal	Translational Research
Volume	198
DOIs	https://doi.org/10.1016/j.trsl.2018.04.003
State	Published - Aug 2018

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Physiology (medical)
Biochemistry, medical

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.trsl.2018.04.003

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title = "Ubiquitin-proteasome signaling in lung injury",

abstract = "Cell homeostasis requires precise coordination of cellular proteins function. Ubiquitination is a post-translational modification that modulates protein half-life and function and is tightly regulated by ubiquitin E3 ligases and deubiquitinating enzymes. Lung injury can progress to acute respiratory distress syndrome that is characterized by an inflammatory response and disruption of the alveolocapillary barrier resulting in alveolar edema accumulation and hypoxemia. Ubiquitination plays an important role in the pathobiology of acute lung injury as it regulates the proteins modulating the alveolocapillary barrier and the inflammatory response. Better understanding of the signaling pathways regulated by ubiquitination may lead to novel therapeutic approaches by targeting specific elements of the ubiquitination pathways.",

author = "Magnani, {Natalia D.} and Dada, {Laura A.} and Sznajder, {Jacob I.}",

note = "Funding Information: This work was supported, in part, by the National Institutes of Health Grants HL48129 , HL-085534 and HL-071643 . Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2018",

month = aug,

doi = "10.1016/j.trsl.2018.04.003",

language = "English (US)",

volume = "198",

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journal = "Translational Research",

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T1 - Ubiquitin-proteasome signaling in lung injury

AU - Magnani, Natalia D.

AU - Dada, Laura A.

AU - Sznajder, Jacob I.

PY - 2018/8

Y1 - 2018/8

N2 - Cell homeostasis requires precise coordination of cellular proteins function. Ubiquitination is a post-translational modification that modulates protein half-life and function and is tightly regulated by ubiquitin E3 ligases and deubiquitinating enzymes. Lung injury can progress to acute respiratory distress syndrome that is characterized by an inflammatory response and disruption of the alveolocapillary barrier resulting in alveolar edema accumulation and hypoxemia. Ubiquitination plays an important role in the pathobiology of acute lung injury as it regulates the proteins modulating the alveolocapillary barrier and the inflammatory response. Better understanding of the signaling pathways regulated by ubiquitination may lead to novel therapeutic approaches by targeting specific elements of the ubiquitination pathways.

AB - Cell homeostasis requires precise coordination of cellular proteins function. Ubiquitination is a post-translational modification that modulates protein half-life and function and is tightly regulated by ubiquitin E3 ligases and deubiquitinating enzymes. Lung injury can progress to acute respiratory distress syndrome that is characterized by an inflammatory response and disruption of the alveolocapillary barrier resulting in alveolar edema accumulation and hypoxemia. Ubiquitination plays an important role in the pathobiology of acute lung injury as it regulates the proteins modulating the alveolocapillary barrier and the inflammatory response. Better understanding of the signaling pathways regulated by ubiquitination may lead to novel therapeutic approaches by targeting specific elements of the ubiquitination pathways.

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DO - 10.1016/j.trsl.2018.04.003

M3 - Review article

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AN - SCOPUS:85049563785

SN - 1931-5244

VL - 198

SP - 29

EP - 39

JO - Translational Research

JF - Translational Research

ER -

Ubiquitin-proteasome signaling in lung injury

Abstract

ASJC Scopus subject areas

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