Ultra-Low Temperature Cryoablation for Atrial Fibrillation: Primary Outcomes for Efficacy and Safety: The Cryocure-2 Study

Tom De Potter*, Martijn Klaver, Alex Babkin, Konstantinos Iliodromitis, Meleze Hocini, Jim Cox, Lucas Boersma

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Ultra-low temperature cryoablation (ULTC) is a novel ablation modality aiming to combine the effectiveness of surgical lesion delivery with percutaneous safety to improve outcomes in catheter ablations of atrial fibrillation, particularly in persistent AF (PsAF). In the Cryocure-2 study (NCT02839304) 78 patients (56.4% PsAF) received ULTC pulmonary vein isolation plus posterior wall ablation, and linear left and right atrial lesions as needed. The safety and acute success of ULTC appear consistent with current catheter ablation techniques and, together with Kaplan-Meier 85.9% 1-year freedom from AF observed in Cryocure-2 PsAF patients, warrant further evaluation in larger clinical trials, which are currently ongoing.

Original languageEnglish (US)
Pages (from-to)1034-1039
Number of pages6
JournalJACC: Clinical Electrophysiology
Volume8
Issue number8
DOIs
StatePublished - Aug 2022

Funding

All study-related costs were funded by Adagio Medical. Dr De Potter has received consulting fees from and owns equity options in Adagio Medical. Dr Babkin has served as a consultant and is a former employee of Adagio Medical. Dr Cox is co-founder and Director of Adagio Medical. Dr Boersma has received consulting fees from Adagio Medical. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.

Keywords

  • atrial fibrillation ablation
  • ultra-low temperature

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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