Ultrafast inverse imaging techniques for fMRI

Fa Hsuan Lin, Kevin W K Tsai, Ying Hua Chu, Thomas Witzel, Aapo Nummenmaa, Tommi Raij, Jyrki Ahveninen, Wen Jui Kuo*, John W. Belliveau

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


Inverse imaging (InI) supercharges the sampling rate of traditional functional MRI 10-100 fold at a cost of a moderate reduction in spatial resolution. The technique is inspired by similarities between multi-sensor magnetoencephalography (MEG) and highly parallel radio-frequency (RF) MRI detector arrays. Using presently available 32-channel head coils at 3T, InI can be sampled at 10. Hz and provides about 5-mm cortical spatial resolution with whole-brain coverage. Here we discuss the present applications of InI, as well as potential future challenges and opportunities in further improving its spatiotemporal resolution and sensitivity. InI may become a helpful tool for clinicians and neuroscientists for revealing the complex dynamics of brain functions during task-related and resting states.

Original languageEnglish (US)
Pages (from-to)699-705
Number of pages7
Issue number2
StatePublished - Aug 15 2012


  • Fast imaging
  • InI
  • Inverse problem
  • Parallel imaging

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience


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