@inproceedings{9a92ba09cf1b464d8f70aef13cfde7f2,
title = "Ultrasensitive detection and depletion of rare leukemic b cells in t cell populations via microfluidics-mediated immunomagnetic cell ranking",
abstract = "Rare leukemic B cells presented in therapeutic T cell populations can cause disease relapse due to their ability to escape from the recognition of T cells. Unfortunately, the traditional cell purification method, such as FACS, is not sensitive enough for rare cell analysis. Here, we implemented our microfluidics-mediated immunomagnetic sorting approach, named magnetic ranking cytometry (MagRC), to enable efficient detection of rare B cells in exceeding T cell background. A quantitative comparison revealed that our MagRC approach outperformed the FACS and achieved a single-cell resolution. We believe the MagRC approach is promising for assessing and improving the safeness of immunotherapy.",
keywords = "Cell Sorting, Cell Therapy, Immunotherapy, Rare Cell",
author = "Zongjie Wang and Kelley, {Shana O.}",
note = "Funding Information: This research was supported in part by the Canadian Institutes of Health Research (grant no. FDN-148415) and the Collaborative Health Research Projects program (CIHR/NSERC partnered). Publisher Copyright: {\textcopyright} 2020 CBMS-0001; 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 ; Conference date: 04-10-2020 Through 09-10-2020",
year = "2020",
language = "English (US)",
series = "MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
publisher = "Chemical and Biological Microsystems Society",
pages = "729--730",
booktitle = "MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
}