Ultrasensitive detection of enzymatic activity with nanowire electrodes

Marcel A. Roberts, Shana O. Kelley*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

Protein detection strategies that will have a positive impact on cancer diagnosis must be highly sensitive, very specific, and utilize time- and cost-effective methods. We report on the development of a method that fulfills these criteria by using a nanowire-based electrode platform that enables use of an electrochemical reporter system for protein detection. The prostate-specific antigen is detected with peptide-modified nanowires. An electrocatalytic reporter system is used to transduce the activity of the enzymes into a measurable electrochemical signal that accurately reports on physiologically relevant picomolar quantities of the analytes.

Original languageEnglish (US)
Pages (from-to)11356-11357
Number of pages2
JournalJournal of the American Chemical Society
Volume129
Issue number37
DOIs
StatePublished - Sep 19 2007
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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