Abstract
Protein detection strategies that will have a positive impact on cancer diagnosis must be highly sensitive, very specific, and utilize time- and cost-effective methods. We report on the development of a method that fulfills these criteria by using a nanowire-based electrode platform that enables use of an electrochemical reporter system for protein detection. The prostate-specific antigen is detected with peptide-modified nanowires. An electrocatalytic reporter system is used to transduce the activity of the enzymes into a measurable electrochemical signal that accurately reports on physiologically relevant picomolar quantities of the analytes.
Original language | English (US) |
---|---|
Pages (from-to) | 11356-11357 |
Number of pages | 2 |
Journal | Journal of the American Chemical Society |
Volume | 129 |
Issue number | 37 |
DOIs | |
State | Published - Sep 19 2007 |
Externally published | Yes |
ASJC Scopus subject areas
- General Chemistry
- Biochemistry
- Catalysis
- Colloid and Surface Chemistry