Ultrasensitive electrocatalytic DNA detection at two- and three-dimensional nanoelectrodes

Rahela Gasparac, Bradford J. Taft, Melissa A. Lapierre-Devlin, Adam D. Lazareck, Jimmy M. Xu, Shana O. Kelley*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

168 Scopus citations

Abstract

Electrochemical DNA detection systems are an attractive approach to the development of multiplexed, high-throughput DNA analysis systems for clinical and research applications. We have engineered a new class of nanoelectrode ensembles (NEEs) that constitute a useful platform for biomolecular electrochemical sensing. High-sensitivity DNA detection was achieved at oligonucleotide-functionalized NEEs using a label-free electrocatalytic assay. Attomole levels of DNA were detected using the NEEs, validating the promise of nanoarchitectures for ultrasensitive biosensing.

Original languageEnglish (US)
Pages (from-to)12270-12271
Number of pages2
JournalJournal of the American Chemical Society
Volume126
Issue number39
DOIs
StatePublished - Oct 6 2004
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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