Ultrasound as a complement to mammography and breast examination to characterize breast masses

Kenneth J W Taylor, Christopher Merritt, Catherine Piccoli, Robert Schmidt, Glenn Rouse, Bruno Fornage, Eva Rubin, Dianne Georgian-Smith, Fred Winsberg, Barry Goldberg, Ellen Mendelson

Research output: Contribution to journalArticlepeer-review

98 Scopus citations


This study was designed to determine if complementary ultrasound (US) imaging and Doppler could decrease the number of biopsies for benign masses. A total of 761 breast masses were sequentially scored on a level of suspicion (LOS) of 1-5, where 1 represented low, and 5 was a high suspicion of malignancy, for mammography, US, and color flow with pulse Doppler (DUS). After biopsy, the results were analyzed using 2 × 2 contingency tables and ROC analysis, for mammography alone and in combination with US and DUS. The addition of US increased the specificity from 51.4% to 66.4% at a prevalence of 31.3% malignancy. ROC analysis showed that the addition of US significantly improved the performance over mammography alone in women < 55 years old (p = 0.049); > 55 years old (p = 0.029); masses < 1 cm (p = 0.016) and masses > 1 cm (p = 0.016). These results show that the addition of US to mammography alone could substantially reduce the number of breast biopsies for benign disease.

Original languageEnglish (US)
Pages (from-to)19-26
Number of pages8
JournalUltrasound in Medicine and Biology
Issue number1
StatePublished - Jan 1 2002


  • Breast biopsy
  • Breast cancer
  • Mammography
  • Ultrasound

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Biophysics
  • Acoustics and Ultrasonics


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