Ultrasound Diagnosis of Prenatal Cleft Lip: How Does Its Accuracy Affect the Family?

Daniel C. Sasson, Alex M. Rokni, Nikhil D. Shah, Selcen S. Yuksel, Eugene Park, Arun K. Gosain*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Factors impacting the accuracy of ultrasound (US) diagnosis of cleft lip (CL) and its subsequent effect on parents are not well understood. Our objectives were to evaluate how the type of CL (complete versus incomplete) and associated cleft palate affect the accuracy of CL's prenatal diagnosis and to evaluate differences between parents' perception of prenatal US in cases of true-positive versus false-negative results. The authors performed a retrospective review of all patients who underwent repair for nonsyndromic CL following prenatal US. Patients were stratified by type of CL and associated cleft palate. Parents were called to determine if their child's CL was diagnosed via US and their perception of the results. Forty-seven children with complete and 40 with incomplete CL responded to phone calls. The presence of a complete CL (P = 0.001) and an associated cleft palate (P = 0.014) were independently associated with an increased likelihood of prenatal diagnosis. Parents who received a true-positive prenatal diagnosis of CL were more satisfied than those who received a false-negative diagnosis (P = 0.0063). True-positives perceived knowing of their child's diagnosis in advance to be more helpful than false-negatives believed it would have been. These results afford an improved context to interpret US studies and help physicians provide more informed prenatal counseling.

Original languageEnglish (US)
Pages (from-to)2468-2470
Number of pages3
JournalJournal of Craniofacial Surgery
Volume32
Issue number7
DOIs
StatePublished - Oct 1 2021

Keywords

  • Cleft lip
  • cleft palate
  • prenatal ultrasound

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

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