Ultrasound-guided percutaneous injection of methylene blue to identify nerve pathology and guide surgery

Joseph A. Osorio, Jonathan D. Breshears, Omar Arnaout, Neil G. Simon, Ashley M. Hastings-Robinson, Pedram Aleshi, Michel Kliot*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Object The objective of this study was to provide a technique that could be used in the preoperative period to facilitate the surgical exploration of peripheral nerve pathology. Methods The authors describe a technique in which 1) ultrasonography is used in the immediate preoperative period to identify target peripheral nerves, 2) an ultrasound-guided needle electrode is used to stimulate peripheral nerves to confirm their position, and then 3) a methylene blue (MB) injection is performed to mark the peripheral nerve pathology to facilitate surgical exploration. Results A cohort of 13 patients with varying indications for peripheral nerve surgery is presented in which ultrasound guidance, stimulation, and MB were used to localize and create a road map for surgeries. Conclusions Preoperative ultrasound-guided MB administration is a promising technique that peripheral nerve surgeons could use to plan and execute surgery.

Original languageEnglish (US)
Article numberE2
JournalNeurosurgical focus
Issue number3
StatePublished - 2015


  • Methylene blue
  • Peripheral nerve
  • Ultrasonography

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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