Ultrastructural damages in rat myocardium induced by hydrogen peroxide injection

S. Sato, Y. Z. Jia, J. Pan

Research output: Contribution to journalArticle

1 Scopus citations


Rat myocardium was examined by electron microscopy after hydrogen peroxide injection through the tail vein. At the initial stage (1-6 hr after injection of hydrogen peroxide), ultrastructural damages included slight edema of the myocytes, dilation of the sarcoplasmic reticulum, disruption of the myofibrils, interstitial edema and the disappearance of elastin. At the early stage (1-7 days), in addition to the ultrastructural damages of the myocardium in the initial stages, swelling and fusion of mitochondria, irregularly-arranged collagen networks and type III bleb formations were observed. At the later stage (14-28 days), tissue damages had recovered. There was little ultrastructural damage in the normal control myocardium. The relationship between oxygen-derived free radicals and early ischemic or ischemia-reperfusion injury is discussed.

Original languageEnglish (US)
Pages (from-to)76-83
Number of pages8
JournalMedical Molecular Morphology
Issue number2
StatePublished - Jan 1 1996


  • Hydrogen peroxide
  • Rat myocardium
  • Transmission electron microscopy
  • Ultrastructural damage

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology

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