Ultrathin Injectable Sensors of Temperature, Thermal Conductivity, and Heat Capacity for Cardiac Ablation Monitoring

Ahyeon Koh, Sarah R. Gutbrod, Jason D. Meyers, Chaofeng Lu, Richard Chad Webb, Gunchul Shin, Yuhang Li, Seung Kyun Kang, Yonggang Huang, Igor R. Efimov*, John A. Rogers

*Corresponding author for this work

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Knowledge of the distributions of temperature in cardiac tissue during and after ablation is important in advancing a basic understanding of this process, and for improving its efficacy in treating arrhythmias. Technologies that enable real-time temperature detection and thermal characterization in the transmural direction can help to predict the depths and sizes of lesion that form. Herein, materials and designs for an injectable device platform that supports precision sensors of temperature and thermal transport properties distributed along the length of an ultrathin and flexible needle-type polymer substrate are introduced. The resulting system can insert into the myocardial tissue, in a minimally invasive manner, to monitor both radiofrequency ablation and cryoablation, in a manner that has no measurable effects on the natural mechanical motions of the heart. The measurement results exhibit excellent agreement with thermal simulations, thereby providing improved insights into lesion transmurality.

Original languageEnglish (US)
Pages (from-to)373-381
Number of pages9
JournalAdvanced Healthcare Materials
Volume5
Issue number3
DOIs
StatePublished - Feb 4 2016

Fingerprint

Thermal Conductivity
Ablation
Specific heat
Thermal conductivity
Hot Temperature
Injections
Temperature
Monitoring
Sensors
Tissue
Equipment Design
Cryosurgery
Needles
Transport properties
Cardiac Arrhythmias
Polymers
Technology
Substrates

Keywords

  • Cardiac ablation monitoring
  • Flexible thermal sensors
  • Lesion transmurality prediction
  • Thermal property detection
  • Transmural thermal detection

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

Cite this

Koh, Ahyeon ; Gutbrod, Sarah R. ; Meyers, Jason D. ; Lu, Chaofeng ; Webb, Richard Chad ; Shin, Gunchul ; Li, Yuhang ; Kang, Seung Kyun ; Huang, Yonggang ; Efimov, Igor R. ; Rogers, John A. / Ultrathin Injectable Sensors of Temperature, Thermal Conductivity, and Heat Capacity for Cardiac Ablation Monitoring. In: Advanced Healthcare Materials. 2016 ; Vol. 5, No. 3. pp. 373-381.
@article{ea738bab70cf426a956c682759bd4bbf,
title = "Ultrathin Injectable Sensors of Temperature, Thermal Conductivity, and Heat Capacity for Cardiac Ablation Monitoring",
abstract = "Knowledge of the distributions of temperature in cardiac tissue during and after ablation is important in advancing a basic understanding of this process, and for improving its efficacy in treating arrhythmias. Technologies that enable real-time temperature detection and thermal characterization in the transmural direction can help to predict the depths and sizes of lesion that form. Herein, materials and designs for an injectable device platform that supports precision sensors of temperature and thermal transport properties distributed along the length of an ultrathin and flexible needle-type polymer substrate are introduced. The resulting system can insert into the myocardial tissue, in a minimally invasive manner, to monitor both radiofrequency ablation and cryoablation, in a manner that has no measurable effects on the natural mechanical motions of the heart. The measurement results exhibit excellent agreement with thermal simulations, thereby providing improved insights into lesion transmurality.",
keywords = "Cardiac ablation monitoring, Flexible thermal sensors, Lesion transmurality prediction, Thermal property detection, Transmural thermal detection",
author = "Ahyeon Koh and Gutbrod, {Sarah R.} and Meyers, {Jason D.} and Chaofeng Lu and Webb, {Richard Chad} and Gunchul Shin and Yuhang Li and Kang, {Seung Kyun} and Yonggang Huang and Efimov, {Igor R.} and Rogers, {John A.}",
year = "2016",
month = "2",
day = "4",
doi = "10.1002/adhm.201500451",
language = "English (US)",
volume = "5",
pages = "373--381",
journal = "Advanced healthcare materials",
issn = "2192-2640",
publisher = "John Wiley and Sons Ltd",
number = "3",

}

Ultrathin Injectable Sensors of Temperature, Thermal Conductivity, and Heat Capacity for Cardiac Ablation Monitoring. / Koh, Ahyeon; Gutbrod, Sarah R.; Meyers, Jason D.; Lu, Chaofeng; Webb, Richard Chad; Shin, Gunchul; Li, Yuhang; Kang, Seung Kyun; Huang, Yonggang; Efimov, Igor R.; Rogers, John A.

In: Advanced Healthcare Materials, Vol. 5, No. 3, 04.02.2016, p. 373-381.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Ultrathin Injectable Sensors of Temperature, Thermal Conductivity, and Heat Capacity for Cardiac Ablation Monitoring

AU - Koh, Ahyeon

AU - Gutbrod, Sarah R.

AU - Meyers, Jason D.

AU - Lu, Chaofeng

AU - Webb, Richard Chad

AU - Shin, Gunchul

AU - Li, Yuhang

AU - Kang, Seung Kyun

AU - Huang, Yonggang

AU - Efimov, Igor R.

AU - Rogers, John A.

PY - 2016/2/4

Y1 - 2016/2/4

N2 - Knowledge of the distributions of temperature in cardiac tissue during and after ablation is important in advancing a basic understanding of this process, and for improving its efficacy in treating arrhythmias. Technologies that enable real-time temperature detection and thermal characterization in the transmural direction can help to predict the depths and sizes of lesion that form. Herein, materials and designs for an injectable device platform that supports precision sensors of temperature and thermal transport properties distributed along the length of an ultrathin and flexible needle-type polymer substrate are introduced. The resulting system can insert into the myocardial tissue, in a minimally invasive manner, to monitor both radiofrequency ablation and cryoablation, in a manner that has no measurable effects on the natural mechanical motions of the heart. The measurement results exhibit excellent agreement with thermal simulations, thereby providing improved insights into lesion transmurality.

AB - Knowledge of the distributions of temperature in cardiac tissue during and after ablation is important in advancing a basic understanding of this process, and for improving its efficacy in treating arrhythmias. Technologies that enable real-time temperature detection and thermal characterization in the transmural direction can help to predict the depths and sizes of lesion that form. Herein, materials and designs for an injectable device platform that supports precision sensors of temperature and thermal transport properties distributed along the length of an ultrathin and flexible needle-type polymer substrate are introduced. The resulting system can insert into the myocardial tissue, in a minimally invasive manner, to monitor both radiofrequency ablation and cryoablation, in a manner that has no measurable effects on the natural mechanical motions of the heart. The measurement results exhibit excellent agreement with thermal simulations, thereby providing improved insights into lesion transmurality.

KW - Cardiac ablation monitoring

KW - Flexible thermal sensors

KW - Lesion transmurality prediction

KW - Thermal property detection

KW - Transmural thermal detection

UR - http://www.scopus.com/inward/record.url?scp=84958655153&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84958655153&partnerID=8YFLogxK

U2 - 10.1002/adhm.201500451

DO - 10.1002/adhm.201500451

M3 - Article

VL - 5

SP - 373

EP - 381

JO - Advanced healthcare materials

JF - Advanced healthcare materials

SN - 2192-2640

IS - 3

ER -