Unbalanced 11;18 translocation in an acute erythroid leukemia after radioactive iodine therapy

Nikolaos A. Trikalinos*, Qing Chen, Yi Ning, Edward A. Sausville, Maria R. Baer

*Corresponding author for this work

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Therapy-related acute myeloid leukemia (t-AML) is well described after chemotherapy or radiotherapy for diverse malignancies. Radioisotope therapy is also recognized as a less-common cause of t-AML. We describe a patient with acute erythroid leukemia after radioactive iodine administration for papillary thyroid cancer, with an unbalanced 11;18 translocation resulting in three copies of 11q, including the MLL gene. Although an increased incidence of chronic myeloid leukemia has been documented after radioactive iodine exposure, acute leukemia in this setting has been less frequently seen. Moreover, to our knowledge, the chromosome abnormality present in our patient has not been previously reported. The literature on cytogenetic abnormalities in t-AML after radioactive iodine administration is reviewed.

Original languageEnglish (US)
Pages (from-to)252-255
Number of pages4
JournalCancer Genetics
Volume206
Issue number6
DOIs
StatePublished - Jun 1 2013

Keywords

  • Acute leukemia
  • Radioactive iodine
  • Therapy-related

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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