Unconventional players on the striated muscle field: MicroRNAs, signaling pathways and epigenetic regulators

Giorgia Giacomazzi, Maurilio Sampaolesi, Mattia Quattrocelli*

*Corresponding author for this work

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Striated muscle regeneration holds an intrinsic complexity governed by many orchestrated events. When the fine balance of regulatory machineries is under strain, the homeostatic conditions are lost and degeneration starts to occur. This is the case for inherited and acquired diseases of both cardiac and skeletal muscles. A wide range of factors are currently under scrutiny for better understanding the details underlying de-/re-generation processes, of both genetic and non-genetic nature. This review focuses on three classes of non-genetic factors regulating striated muscle regeneration, i.e. microRNAs, signaling pathways and epigenetic regulators.

Original languageEnglish (US)
Pages (from-to)554-560
Number of pages7
JournalCurrent Stem Cell Research and Therapy
Volume11
Issue number7
DOIs
StatePublished - Jan 1 2016

Keywords

  • Epigenetic factors
  • MicroRNAs
  • Non-genetic factors
  • Regeneration
  • Signaling pathways
  • Striated muscle

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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