TY - JOUR
T1 - Unconventional players on the striated muscle field
T2 - MicroRNAs, signaling pathways and epigenetic regulators
AU - Giacomazzi, Giorgia
AU - Sampaolesi, Maurilio
AU - Quattrocelli, Mattia
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Striated muscle regeneration holds an intrinsic complexity governed by many orchestrated events. When the fine balance of regulatory machineries is under strain, the homeostatic conditions are lost and degeneration starts to occur. This is the case for inherited and acquired diseases of both cardiac and skeletal muscles. A wide range of factors are currently under scrutiny for better understanding the details underlying de-/re-generation processes, of both genetic and non-genetic nature. This review focuses on three classes of non-genetic factors regulating striated muscle regeneration, i.e. microRNAs, signaling pathways and epigenetic regulators.
AB - Striated muscle regeneration holds an intrinsic complexity governed by many orchestrated events. When the fine balance of regulatory machineries is under strain, the homeostatic conditions are lost and degeneration starts to occur. This is the case for inherited and acquired diseases of both cardiac and skeletal muscles. A wide range of factors are currently under scrutiny for better understanding the details underlying de-/re-generation processes, of both genetic and non-genetic nature. This review focuses on three classes of non-genetic factors regulating striated muscle regeneration, i.e. microRNAs, signaling pathways and epigenetic regulators.
KW - Epigenetic factors
KW - MicroRNAs
KW - Non-genetic factors
KW - Regeneration
KW - Signaling pathways
KW - Striated muscle
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U2 - 10.2174/1574888X10666150113111320
DO - 10.2174/1574888X10666150113111320
M3 - Review article
C2 - 25584907
AN - SCOPUS:84989266612
VL - 11
SP - 554
EP - 560
JO - Current Stem Cell Research and Therapy
JF - Current Stem Cell Research and Therapy
SN - 1574-888X
IS - 7
ER -