Unconventional players on the striated muscle field: MicroRNAs, signaling pathways and epigenetic regulators

Giorgia Giacomazzi; Maurilio Sampaolesi; Mattia Quattrocelli

doi:10.2174/1574888X10666150113111320

Unconventional players on the striated muscle field: MicroRNAs, signaling pathways and epigenetic regulators

Giorgia Giacomazzi, Maurilio Sampaolesi, Mattia Quattrocelli^*

^*Corresponding author for this work

Pharmacology

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Striated muscle regeneration holds an intrinsic complexity governed by many orchestrated events. When the fine balance of regulatory machineries is under strain, the homeostatic conditions are lost and degeneration starts to occur. This is the case for inherited and acquired diseases of both cardiac and skeletal muscles. A wide range of factors are currently under scrutiny for better understanding the details underlying de-/re-generation processes, of both genetic and non-genetic nature. This review focuses on three classes of non-genetic factors regulating striated muscle regeneration, i.e. microRNAs, signaling pathways and epigenetic regulators.

Original language	English (US)
Pages (from-to)	554-560
Number of pages	7
Journal	Current Stem Cell Research and Therapy
Volume	11
Issue number	7
DOIs	https://doi.org/10.2174/1574888X10666150113111320
State	Published - Jan 1 2016

Keywords

Epigenetic factors
MicroRNAs
Non-genetic factors
Regeneration
Signaling pathways
Striated muscle

ASJC Scopus subject areas

Medicine (miscellaneous)

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10.2174/1574888X10666150113111320

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abstract = "Striated muscle regeneration holds an intrinsic complexity governed by many orchestrated events. When the fine balance of regulatory machineries is under strain, the homeostatic conditions are lost and degeneration starts to occur. This is the case for inherited and acquired diseases of both cardiac and skeletal muscles. A wide range of factors are currently under scrutiny for better understanding the details underlying de-/re-generation processes, of both genetic and non-genetic nature. This review focuses on three classes of non-genetic factors regulating striated muscle regeneration, i.e. microRNAs, signaling pathways and epigenetic regulators.",

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AU - Giacomazzi, Giorgia

AU - Sampaolesi, Maurilio

AU - Quattrocelli, Mattia

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AB - Striated muscle regeneration holds an intrinsic complexity governed by many orchestrated events. When the fine balance of regulatory machineries is under strain, the homeostatic conditions are lost and degeneration starts to occur. This is the case for inherited and acquired diseases of both cardiac and skeletal muscles. A wide range of factors are currently under scrutiny for better understanding the details underlying de-/re-generation processes, of both genetic and non-genetic nature. This review focuses on three classes of non-genetic factors regulating striated muscle regeneration, i.e. microRNAs, signaling pathways and epigenetic regulators.

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KW - Non-genetic factors

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KW - Signaling pathways

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Unconventional players on the striated muscle field: MicroRNAs, signaling pathways and epigenetic regulators

Abstract

Keywords

ASJC Scopus subject areas

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