Unconventional Roles of Cytoskeletal Mitotic Machinery in Neurodevelopment

Urko del Castillo, Rosalind Norkett, Vladimir I. Gelfand*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


At first look, cell division and neurite formation seem to be two different, essential biological processes. However, both processes require extensive reorganization of the cytoskeleton, and especially microtubules. Remarkably, in recent years, independent work from several groups has shown that multiple cytoskeletal components previously considered specific for the mitotic machinery play important roles in neurite initiation and extension. In this review article, we describe how several cytoplasmic and mitotic microtubule motors, components of mitotic kinetochores, and cortical actin participate in reorganization of the microtubule network required to form and maintain axons and dendrites. The emerging similarities between these two biological processes will certainly generate new insights into the mechanisms generating the unique morphology of neurons.

Original languageEnglish (US)
Pages (from-to)901-911
Number of pages11
JournalTrends in Cell Biology
Issue number11
StatePublished - Nov 2019


  • cell division
  • cytoskeleton
  • microtubules
  • motor
  • neurites
  • neuron
  • sliding

ASJC Scopus subject areas

  • Cell Biology


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