Understanding ciliated epithelia: The power of Xenopus

M. E. Werner, B. J. Mitchell*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

53 Scopus citations

Abstract

Ciliated epithelia are important in a wide variety of biological contexts where they generate directed fluid flow. Here we address the fundamental advances in understanding ciliated epithelia that have been achieved using Xenopus as a model system. Xenopus embryos are covered with a ciliated epithelium that propels fluid unidirectionally across their surface. The external nature of this tissue, coupled with the molecular tools available in Xenopus and the ease of microscopic analysis on intact animals has thrust Xenopus to the forefront of ciliated epithelia biology. We discuss advances in understanding the molecular regulators of ciliated epithelia cell fate as well as basic aspects of ciliated epithelia cell biology including ciliogenesis and cell polarity.

Original languageEnglish (US)
Pages (from-to)176-185
Number of pages10
JournalGenesis
Volume50
Issue number3
DOIs
StatePublished - Mar 2012

Keywords

  • Cell fate specification
  • Cilia
  • Ciliogenesis
  • Planar cell polarity
  • Xenopus

ASJC Scopus subject areas

  • Genetics
  • Endocrinology
  • Cell Biology

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