Understanding Staphylococcus aureus in hyperglycaemia: A review of virulence factor and metabolic adaptations

Madeline J. O'Connor; Angelica V. Bartler; Kelly C. Ho; Kenneth Zhang; Rolando J. Casas Fuentes; Bradley A. Melnick; Kristin N. Huffman; Seok Jong Hong; Robert D. Galiano

doi:10.1111/wrr.13192

Understanding Staphylococcus aureus in hyperglycaemia: A review of virulence factor and metabolic adaptations

Madeline J. O'Connor, Angelica V. Bartler, Kelly C. Ho, Kenneth Zhang, Rolando J. Casas Fuentes, Bradley A. Melnick, Kristin N. Huffman, Seok Jong Hong, Robert D. Galiano^*

^*Corresponding author for this work

Surgery, Plastic Surgery Division

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Staphylococcus aureus is one of the most commonly detected bacteria in diabetic skin and soft tissue infections. The incidence and severity of skin and soft tissue infections are higher in patients with diabetes, indicating a potentiating mechanism of hyperglycaemia and infection. The goal of this review is to explore the metabolic and virulence factor adaptations of S. aureus under hyperglycaemic conditions. Primary data from identified studies were included and summarised in this paper. Understanding the nexus of hyperglycaemia, metabolism, and virulence factors provides insights into the complexity of diabetic skin and soft tissue infections attributed to S. aureus.

Original language	English (US)
Pages (from-to)	661-670
Number of pages	10
Journal	Wound Repair and Regeneration
Volume	32
Issue number	5
DOIs	https://doi.org/10.1111/wrr.13192
State	Published - Sep 1 2024

Keywords

diabetes
metabolic adaptations
soft tissue infection
virulence factors

ASJC Scopus subject areas

Surgery
Dermatology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/wrr.13192

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title = "Understanding Staphylococcus aureus in hyperglycaemia: A review of virulence factor and metabolic adaptations",

abstract = "Staphylococcus aureus is one of the most commonly detected bacteria in diabetic skin and soft tissue infections. The incidence and severity of skin and soft tissue infections are higher in patients with diabetes, indicating a potentiating mechanism of hyperglycaemia and infection. The goal of this review is to explore the metabolic and virulence factor adaptations of S. aureus under hyperglycaemic conditions. Primary data from identified studies were included and summarised in this paper. Understanding the nexus of hyperglycaemia, metabolism, and virulence factors provides insights into the complexity of diabetic skin and soft tissue infections attributed to S. aureus.",

keywords = "diabetes, metabolic adaptations, soft tissue infection, virulence factors",

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doi = "10.1111/wrr.13192",

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journal = "Wound Repair and Regeneration",

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AU - Ho, Kelly C.

AU - Zhang, Kenneth

AU - Casas Fuentes, Rolando J.

AU - Melnick, Bradley A.

AU - Huffman, Kristin N.

AU - Hong, Seok Jong

AU - Galiano, Robert D.

PY - 2024/9/1

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N2 - Staphylococcus aureus is one of the most commonly detected bacteria in diabetic skin and soft tissue infections. The incidence and severity of skin and soft tissue infections are higher in patients with diabetes, indicating a potentiating mechanism of hyperglycaemia and infection. The goal of this review is to explore the metabolic and virulence factor adaptations of S. aureus under hyperglycaemic conditions. Primary data from identified studies were included and summarised in this paper. Understanding the nexus of hyperglycaemia, metabolism, and virulence factors provides insights into the complexity of diabetic skin and soft tissue infections attributed to S. aureus.

AB - Staphylococcus aureus is one of the most commonly detected bacteria in diabetic skin and soft tissue infections. The incidence and severity of skin and soft tissue infections are higher in patients with diabetes, indicating a potentiating mechanism of hyperglycaemia and infection. The goal of this review is to explore the metabolic and virulence factor adaptations of S. aureus under hyperglycaemic conditions. Primary data from identified studies were included and summarised in this paper. Understanding the nexus of hyperglycaemia, metabolism, and virulence factors provides insights into the complexity of diabetic skin and soft tissue infections attributed to S. aureus.

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KW - metabolic adaptations

KW - soft tissue infection

KW - virulence factors

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Understanding Staphylococcus aureus in hyperglycaemia: A review of virulence factor and metabolic adaptations

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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