Understanding the implications of diabetes on the vascular system

Zachary M. Emond, Melina R. Kibbe*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Patients with diabetes comprise an extremely complex subset of patients for the vascular surgeon. Often, they have numerous comorbidities that can further complicate matters. The diabetic environment is highly complex and the interplay of various diseases makes this an extremely challenging condition to manage. Knowing the mechanisms by which diabetes inflicts adverse microscopic changes in the vasculature allows the clinician to anticipate problems and minimize the heightened risks observed in diabetic patients undergoing surgery. In this review, we will illustrate how diabetes affects the vasculature and how the molecular and cellular derangements that occur in diabetic environments lead to these pathophysiologic consequences.

Original languageEnglish (US)
Pages (from-to)481-489
Number of pages9
JournalVascular and Endovascular Surgery
Volume45
Issue number6
DOIs
StatePublished - Aug 1 2011

Keywords

  • diabetes
  • endothelial progenitor cells
  • insulin
  • neointimal hyperplasia
  • reactive oxygen species
  • vasculature

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine

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