Understanding the spectrum of sinus venosus interatrial communications

Justin T. Tretter, Sathish Chikkabyrappa, DIane E. Spicer, Carl L Backer, Ralph S. Mosca, Robert H. Anderson, Puneet Bhatla*

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background It is still thought by some that a common wall is to be found in the normal heart between the attachments of the caval and pulmonary veins, with absence of this wall underscoring the presence of sinus venosus defects. Recent findings using episcopic microscopy in developing mice have shown the deficiencies of this notion. Understanding that the superior rim of the oval fossa is a fold, rather than a true septum, which can be distorted in the presence of partially anomalous pulmonary venous drainage, has provided an alternative explanation for the morphogenesis of sinus venosus defects. Methods We reviewed our experience with patients suspected of having a sinus venosus defect from August, 2011, through October, 2015, analysing the findings in light of the current hypotheses used to explain the development of the defects, along with correlations made by inspection of autopsy specimens. Results We evaluated findings from 16 patients, with a mean age of 7.7 years, ranging from 2.7 to 15 years. Of the group, 13 were ultimately diagnosed with a superior sinus venosus defect, two with an inferior defect, and one with isolated anomalous pulmonary venous connection in the absence of an interatrial communication. Initially, two patients were thought to have oval fossa defects, one from each subtype, but were correctly diagnosed following cardiac magnetic resonance interrogation. Anomalous pulmonary venous connections were present in all cases. Conclusion Appreciation of the changes occurring during normal cardiac development helps in understanding the anatomical substrate underscoring the spectrum of sinus venosus defects. The lesions are veno-venous connections due to partially anomalous pulmonary venous connections, producing interatrial communications outside the confines of the interatrial septum.

Original languageEnglish (US)
Pages (from-to)418-426
Number of pages9
JournalCardiology in the Young
Volume27
Issue number3
DOIs
StatePublished - Mar 1 2017

Fingerprint

Communication
Lung
Venae Cavae
Pulmonary Veins
Morphogenesis
Drainage
Microscopy
Autopsy
Magnetic Resonance Spectroscopy

Keywords

  • Sinus venosus defect
  • anomalous pulmonary vein
  • atrial septal defect
  • cardiac development

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Cardiology and Cardiovascular Medicine

Cite this

Tretter, J. T., Chikkabyrappa, S., Spicer, DI. E., Backer, C. L., Mosca, R. S., Anderson, R. H., & Bhatla, P. (2017). Understanding the spectrum of sinus venosus interatrial communications. Cardiology in the Young, 27(3), 418-426. https://doi.org/10.1017/S1047951116000664
Tretter, Justin T. ; Chikkabyrappa, Sathish ; Spicer, DIane E. ; Backer, Carl L ; Mosca, Ralph S. ; Anderson, Robert H. ; Bhatla, Puneet. / Understanding the spectrum of sinus venosus interatrial communications. In: Cardiology in the Young. 2017 ; Vol. 27, No. 3. pp. 418-426.
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Tretter, JT, Chikkabyrappa, S, Spicer, DIE, Backer, CL, Mosca, RS, Anderson, RH & Bhatla, P 2017, 'Understanding the spectrum of sinus venosus interatrial communications', Cardiology in the Young, vol. 27, no. 3, pp. 418-426. https://doi.org/10.1017/S1047951116000664

Understanding the spectrum of sinus venosus interatrial communications. / Tretter, Justin T.; Chikkabyrappa, Sathish; Spicer, DIane E.; Backer, Carl L; Mosca, Ralph S.; Anderson, Robert H.; Bhatla, Puneet.

In: Cardiology in the Young, Vol. 27, No. 3, 01.03.2017, p. 418-426.

Research output: Contribution to journalArticle

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AU - Tretter, Justin T.

AU - Chikkabyrappa, Sathish

AU - Spicer, DIane E.

AU - Backer, Carl L

AU - Mosca, Ralph S.

AU - Anderson, Robert H.

AU - Bhatla, Puneet

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N2 - Background It is still thought by some that a common wall is to be found in the normal heart between the attachments of the caval and pulmonary veins, with absence of this wall underscoring the presence of sinus venosus defects. Recent findings using episcopic microscopy in developing mice have shown the deficiencies of this notion. Understanding that the superior rim of the oval fossa is a fold, rather than a true septum, which can be distorted in the presence of partially anomalous pulmonary venous drainage, has provided an alternative explanation for the morphogenesis of sinus venosus defects. Methods We reviewed our experience with patients suspected of having a sinus venosus defect from August, 2011, through October, 2015, analysing the findings in light of the current hypotheses used to explain the development of the defects, along with correlations made by inspection of autopsy specimens. Results We evaluated findings from 16 patients, with a mean age of 7.7 years, ranging from 2.7 to 15 years. Of the group, 13 were ultimately diagnosed with a superior sinus venosus defect, two with an inferior defect, and one with isolated anomalous pulmonary venous connection in the absence of an interatrial communication. Initially, two patients were thought to have oval fossa defects, one from each subtype, but were correctly diagnosed following cardiac magnetic resonance interrogation. Anomalous pulmonary venous connections were present in all cases. Conclusion Appreciation of the changes occurring during normal cardiac development helps in understanding the anatomical substrate underscoring the spectrum of sinus venosus defects. The lesions are veno-venous connections due to partially anomalous pulmonary venous connections, producing interatrial communications outside the confines of the interatrial septum.

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KW - Sinus venosus defect

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Tretter JT, Chikkabyrappa S, Spicer DIE, Backer CL, Mosca RS, Anderson RH et al. Understanding the spectrum of sinus venosus interatrial communications. Cardiology in the Young. 2017 Mar 1;27(3):418-426. https://doi.org/10.1017/S1047951116000664