TY - JOUR
T1 - Undifferentiated embryonal sarcoma and the role of liver transplantation
AU - Plumblee, Leah
AU - Grey, H.
AU - Hudspeth, Michelle
AU - Nadig, Satish
N1 - Publisher Copyright:
© 2019
PY - 2019/10
Y1 - 2019/10
N2 - Undifferentiated embryonal sarcoma of the liver (UESL) is a rare but aggressive pediatric tumor. Historically, treatment for UESL has consisted of combination therapy with surgical resection and chemotherapy. In some cases, surgical resection is not appropriate due to limiting factors such as tumor size, location, and lack of response to treatment. Orthotopic liver transplant (OLT) has been suggested as a promising alternative in these cases. We present a case of an 8 year-old boy with a large undifferentiated embryonal sarcoma of the liver who experienced disease progression after initial neoadjuvant chemotherapy. His tumor was considered unresectable after internal tumor board review due to its size and significant vascularity, ultimately making OLT the only curative option for this patient.
AB - Undifferentiated embryonal sarcoma of the liver (UESL) is a rare but aggressive pediatric tumor. Historically, treatment for UESL has consisted of combination therapy with surgical resection and chemotherapy. In some cases, surgical resection is not appropriate due to limiting factors such as tumor size, location, and lack of response to treatment. Orthotopic liver transplant (OLT) has been suggested as a promising alternative in these cases. We present a case of an 8 year-old boy with a large undifferentiated embryonal sarcoma of the liver who experienced disease progression after initial neoadjuvant chemotherapy. His tumor was considered unresectable after internal tumor board review due to its size and significant vascularity, ultimately making OLT the only curative option for this patient.
KW - Orthotopic liver transplant
KW - Pediatric liver transplantation
KW - Pediatric liver tumors
KW - Undifferentiated embryonal sarcoma of the liver
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U2 - 10.1016/j.epsc.2019.101284
DO - 10.1016/j.epsc.2019.101284
M3 - Article
AN - SCOPUS:85070544755
SN - 2213-5766
VL - 49
JO - Journal of Pediatric Surgery Case Reports
JF - Journal of Pediatric Surgery Case Reports
M1 - 101284
ER -