TY - JOUR
T1 - Undifferentiated (embryonal) sarcoma of the liver
T2 - Ultrastructure, immunohistochemistry, and DNA ploidy analysis of two cases
AU - Chou, Pauline
AU - Mangkornkanok, Marayart
AU - Gonzalez-Crussi, F.
PY - 1990
Y1 - 1990
N2 - We describe the histopathologic, immunohistochemical, electronmicroscopic features, and DNA flow cytometric analysis of 2 cases of undifferentiated (embryonal) sarcoma of the liver. The tumor cells were found to be uniformly nonreactive to antibodies that identify cells belonging to the macrophagic-monocytic system. Focal expression of cytokeratin was an unexpected finding. We conclude that the observations are compatible with origin of this sarcoma from primitive mesenchyme. Uncertainty still exists about histogenesis, but the morphologic features of this neoplasm are quite characteristic. Both tumors demonstrate aneuploid stem lines with high S phase. Whether these findings are prognostically significant remains to be seen..
AB - We describe the histopathologic, immunohistochemical, electronmicroscopic features, and DNA flow cytometric analysis of 2 cases of undifferentiated (embryonal) sarcoma of the liver. The tumor cells were found to be uniformly nonreactive to antibodies that identify cells belonging to the macrophagic-monocytic system. Focal expression of cytokeratin was an unexpected finding. We conclude that the observations are compatible with origin of this sarcoma from primitive mesenchyme. Uncertainty still exists about histogenesis, but the morphologic features of this neoplasm are quite characteristic. Both tumors demonstrate aneuploid stem lines with high S phase. Whether these findings are prognostically significant remains to be seen..
KW - Cytokeratin
KW - DNA analysis
KW - Undifferentiated (embryonal) sarcoma
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U2 - 10.3109/15513819009067143
DO - 10.3109/15513819009067143
M3 - Article
C2 - 2371180
AN - SCOPUS:0025064866
VL - 10
SP - 549
EP - 562
JO - Pediatric Pathology and Molecular Medicine
JF - Pediatric Pathology and Molecular Medicine
SN - 1551-3815
IS - 4
ER -