Undifferentiated (embryonal) sarcoma of the liver: Ultrastructure, immunohistochemistry, and DNA ploidy analysis of two cases

Pauline Chou*, Marayart Mangkornkanok, F. Gonzalez-Crussi

*Corresponding author for this work

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

We describe the histopathologic, immunohistochemical, electronmicroscopic features, and DNA flow cytometric analysis of 2 cases of undifferentiated (embryonal) sarcoma of the liver. The tumor cells were found to be uniformly nonreactive to antibodies that identify cells belonging to the macrophagic-monocytic system. Focal expression of cytokeratin was an unexpected finding. We conclude that the observations are compatible with origin of this sarcoma from primitive mesenchyme. Uncertainty still exists about histogenesis, but the morphologic features of this neoplasm are quite characteristic. Both tumors demonstrate aneuploid stem lines with high S phase. Whether these findings are prognostically significant remains to be seen..

Original languageEnglish (US)
Pages (from-to)549-562
Number of pages14
JournalFetal and Pediatric Pathology
Volume10
Issue number4
DOIs
StatePublished - Jan 1 1990

Keywords

  • Cytokeratin
  • DNA analysis
  • Undifferentiated (embryonal) sarcoma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

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