TY - JOUR
T1 - Undifferentiated sarcoma of the liver
T2 - A case study of an erythropoietin-secreting tumor
AU - Lin, Joann M.
AU - Heath, Jonathon E.
AU - Twaddell, William S.
AU - Castellani, Rudy J.
PY - 2014/9
Y1 - 2014/9
N2 - Undifferentiated embryonal sarcoma of the liver (UESL) is an uncommon hepatic tumor usually found in children, with rare cases reported in adults. We present a case of a 53-year-old woman with an undifferentiated sarcoma of the liver (USL), which resembles UESL, who initially presented with a markedly elevated hematocrit (61.2%). Cytogenetic studies for polycythemia vera were negative, but the patient's erythropoietin (EPO) was elevated. A computed tomography scan and subsequent partial hepatectomy revealed a well-circumscribed, partially cystic mass in the right lobe of the liver measuring 34 cm. Following surgery, the patient's EPO level and hematocrit dropped to within normal range and remained so for 1 year, at which point it rose again. A subsequent magnetic resonance imaging scan showed a liver mass at the previous resection margin, consistent with a recurrence. In this case study, we describe the first reported USL resembling an UESL that secretes EPO, which was a useful marker of tumor recurrence.
AB - Undifferentiated embryonal sarcoma of the liver (UESL) is an uncommon hepatic tumor usually found in children, with rare cases reported in adults. We present a case of a 53-year-old woman with an undifferentiated sarcoma of the liver (USL), which resembles UESL, who initially presented with a markedly elevated hematocrit (61.2%). Cytogenetic studies for polycythemia vera were negative, but the patient's erythropoietin (EPO) was elevated. A computed tomography scan and subsequent partial hepatectomy revealed a well-circumscribed, partially cystic mass in the right lobe of the liver measuring 34 cm. Following surgery, the patient's EPO level and hematocrit dropped to within normal range and remained so for 1 year, at which point it rose again. A subsequent magnetic resonance imaging scan showed a liver mass at the previous resection margin, consistent with a recurrence. In this case study, we describe the first reported USL resembling an UESL that secretes EPO, which was a useful marker of tumor recurrence.
KW - embryonal sarcoma
KW - erythropoietin
KW - hepatic
KW - undifferentiated sarcoma
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U2 - 10.1177/1066896913503490
DO - 10.1177/1066896913503490
M3 - Article
C2 - 24038117
AN - SCOPUS:84906231096
SN - 1066-8969
VL - 22
SP - 555
EP - 558
JO - International Journal of Surgical Pathology
JF - International Journal of Surgical Pathology
IS - 6
ER -