Unexpected roles for deacetylation in interferon- and cytokine-induced transcription

Inna Nusinzon*, Curt M. Horvath

*Corresponding author for this work

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

Protein acetylation is a reversible modification that has been implicated in epigenetic regulation of gene expression. It is widely accepted that acetylation enzymes are present at transcriptionally active promoters and deacetylation enzymes associate with transcriptionally silent loci. These results notwithstanding, recent findings indicate that positive regulation of gene expression by interferons and other cytokines requires both acetylation and deacetylation.

Original languageEnglish (US)
Pages (from-to)745-748
Number of pages4
JournalJournal of Interferon and Cytokine Research
Volume25
Issue number12
DOIs
StatePublished - Dec 1 2005

ASJC Scopus subject areas

  • Immunology
  • Cell Biology
  • Virology

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