Unidirectional fluxes of rhodamine 123 in multidrug-resistant cells: Evidence against direct drug extrusion from the plasma membrane

Keyphrases

• Plasma Membrane 100%
• Resistant Cells 100%
• P-glycoprotein (P-gp) 100%
• Rhodamine 123 100%
• Drug Extrusion 100%
• Unidirectional Flux 100%
• P-glycoprotein Expression 42%
• Vacuum Cleaner 42%
• Flippase 42%
• Efflux 28%
• Fibroblasts 14%
• Cell Membrane 14%
• Possible Mechanisms 14%
• Mitochondria 14%
• External Medium 14%
• ATP Synthase 14%
• Chinese Hamster 14%
• Cytotoxic Drugs 14%
• Lipid Bilayer 14%
• Fluorescent Dye 14%
• Plasma Membrane Proteins 14%
• Hydrophobic Substrates 14%
• Outer Leaflet 14%
• Multidrug Resistant Tumor Cells 14%
• Medium Vacuum 14%
• P-glycoprotein Transporter 14%
• P-glycoprotein Inhibitor 14%

Biochemistry, Genetics and Molecular Biology

• Rhodamine 123 100%
• Cell Membrane 100%
• P-Glycoprotein 100%
• Flippase 25%
• Lipid Bilayer 8%
• Mitochondrion 8%
• Chinese Hamster 8%
• Drug Transport 8%
• ATPase 8%
• Transmembrane Protein 8%
• Membrane Protein 8%
• Fibroblast 8%

Pharmacology, Toxicology and Pharmaceutical Science

• P-Glycoprotein 100%
• Rhodamine 123 100%
• Effusion 18%
• Drug Transport 9%
• Membrane Protein 9%
• Adenosine Triphosphatase 9%
• Fluorescent Dye 9%
• Glycoprotein P Inhibitor 9%
• Neoplasm 9%
• Chinese Hamster 9%
• Cytotoxic Agent 9%